Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

• Published in: Antioxidants Vol. 12; no. 4; p. 901
• Main Authors: Bardelčíková, Annamária, Šoltys, Jindřich, Mojžiš, Ján
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Cancer; Cell survival; Chronic illnesses; Colorectal cancer; Colorectal carcinoma; Cytokines; Dehydrogenases; Disease; DNA damage; Free radicals; Health risk assessment; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Lipids; Long-term effects; Mitochondria; Oxidation; Oxidative stress; Pathogenesis; Physiological aspects; Physiology; Remission (Medicine); Review; Transcription activation; Transcription factors; Tumorigenesis; United States; Europe; colorectal carcinoma; inflammation; inflammatory bowel disease; oxidative stress
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox12040901

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in the initiation and development of CRC. Although OS plays a vital part in the life of all organisms, its long-term effects on the human body may be involved in the development of different chronic diseases, including cancer diseases. Chronic OS can lead to the oxidation of biomolecules (nucleic acids, lipids and proteins) or the activation of inflammatory signaling pathways, resulting in the activation of several transcription factors or the dysregulation of gene and protein expression followed by tumor initiation or cancer cell survival. In addition, it is well known that chronic intestinal diseases such as inflammatory bowel disease (IBD) are associated with an increased risk of cancer, and a link between OS and IBD initiation and progression has been reported. This review focuses on the role of oxidative stress as a causative agent of inflammation in colorectal cancer.