Multidrug-resistant Mycobacterium tuberculosis strain from Equatorial Guinea detected in Spain

• Published in: Emerging infectious diseases Vol. 15; no. 11; pp. 1858 - 1860
• Main Authors: Gavín, Patricia, Iglesias, Maria J, Jiménez, Maria S, Herrera-Leon, Laura, Rodríguez-Valín, Elena, Rastogi, Nalin, March, Josefa, González-Palacios, Rosa, Palenque, Elia, Ayarza, Rafael, Hurra, Elena, Campos-Herrero, Isolina, Vitoria, María A, Lezcano, María A, Revillo, María J, Martin, Carlos, Samper, Sofía
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.11.2009; Centers for Disease Control and Prevention
• Subjects: Adolescent; Adult; Bacteriology; Child; Communicable Diseases, Emerging; Communicable Diseases, Emerging - drug therapy; Communicable Diseases, Emerging - epidemiology; Communicable Diseases, Emerging - microbiology; Drug resistance in microorganisms; Drug Resistance, Multiple, Bacterial; Drug Resistance, Multiple, Bacterial - genetics; Emigrants and Immigrants; Equatorial Guinea; Equatorial Guinea - ethnology; Female; Genes, Bacterial; Genetic aspects; Health aspects; Humans; Identification and classification; letter; Letters to the Editor; Life Sciences; Male; Methods; Microbiology and Parasitology; Middle Aged; Molecular Epidemiology; multidrug-resistant; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - isolation & purification; Prevalence studies (Epidemiology); Spain; Spain - epidemiology; transmission; Tuberculosis; Tuberculosis, Pulmonary; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - microbiology; Young Adult; Equatorial Guinea; Spain; Mycobacterium; "SITVIT2"; "Equatorial Guinea"; "Spoligotyping"; Multidrug-Resistant; Spoligotyping; IS6110-RFLP; "Tuberculosis"; Equatorial Guinea; Epidemiology; Immigrants; "Epidemiology"; "Immigrants"; Spain; "Mycobacterium"; SITVIT2; Tuberculosis; "Spain"; "MIRU-VNTR"; MIRU-VNTR; "IS6110-RFLP"; "Multidrug-Resistant"
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid1511.090449

This investigation focused on a specific Multidrug-Resistant (MDR) Mycobacterium tuberculosis strain from Equatorial Guinea that had been imported into Spain. Ten MDR isolates from as many patients from Equatorial Guinea were detected in Spain during 2000 through 2008. All the 10 isolates exhibited an identical genotypic pattern belonging to the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis designated SIT177-LAM 9. Evidence of clonality was found for all the 10 isolates by different molecular epidemiology methods and mutations involved in drug resistance. The analysis of the RDRio deletion confirmed that the strain belonged to the major RDRio sublineage of the Latin-American and Mediterranean (LAM) genotypic lineage of M. tuberculosis which has disseminated globally.