Segregating domain-general from emotional context-specific inhibitory control systems - ventral striatum and orbitofrontal cortex serve as emotion-cognition integration hubs

• Published in: NeuroImage (Orlando, Fla.) Vol. 238; p. 118269
• Main Authors: Zhuang, Qian, Xu, Lei, Zhou, Feng, Yao, Shuxia, Zheng, Xiaoxiao, Zhou, Xinqi, Li, Jialin, Xu, Xiaolei, Fu, Meina, Li, Keshuang, Vatansever, Deniz, Kendrick, Keith M., Becker, Benjamin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.09.2021; Elsevier Limited; Elsevier
• Subjects: Animal cognition; Behavior; Brain; Brain mapping; Caudate-putamen; Cognition & reasoning; Cognitive ability; Domain-general; Emotion; Emotional behavior; Emotional Go/No Go; Emotions; Frontal gyrus; Functional magnetic resonance imaging; Inhibition; Medical imaging; Neostriatum; Neural networks; Prefrontal cortex; Striatum; Striatum; Inhibition; Emotion; Prefrontal cortex; Emotional Go/No Go; Domain-general
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118269

Inhibitory control hierarchically regulates cognitive and emotional systems in the service of adaptive goal-directed behavior across changing task demands and environments. While previous studies convergently determined the contribution of prefrontal-striatal systems to general inhibitory control, findings on the specific circuits that mediate emotional context-specific impact on inhibitory control remained inconclusive. Against this background we combined an evaluated emotional Go/No Go task with fMRI in a large cohort of subjects (N=250) to segregate brain systems and circuits that mediate domain-general from emotion-specific inhibitory control. Particularly during a positive emotional context, behavioral results showed a lower accuracy for No Go trials and a faster response time for Go trials. While the dorsal striatum and lateral frontal regions were involved in inhibitory control irrespective of emotional context, activity in the ventral striatum (VS) and medial orbitofrontal cortex (mOFC) varied as a function of emotional context. On the voxel-wise whole-brain network level, limbic and striatal systems generally exhibited highest changes in global brain connectivity during inhibitory control, while global brain connectivity of the left mOFC was less decreased during emotional contexts. Functional connectivity analyses moreover revealed that negative coupling between the VS with inferior frontal gyrus (IFG)/insula and mOFC varied as a function of emotional context. Together these findings indicate separable domain- general as well as emotional context-specific inhibitory brain systems which specifically encompass the VS and its connections with frontal regions.