Concurrent Onset of Chronic Lymphocytic Leukemia and Atypical Phenotype Acute Myeloid Leukemia Revealed by Autopsy

Abstract The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite...

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Published inCase reports in oncology Vol. 14; no. 3; pp. 1725 - 1732
Main Authors Kiso, Sayaka, Sugiura, Hiroyuki, Kuroi, Taiga, Omote, Rika, Toji, Tomohiro, Ishikawa, Tatsunori, Okamoto, Sachiyo, Nomura, Naho, Masunari, Taro, Sezaki, Nobuo, Kiguchi, Toru, Tanimoto, Mitsune
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 30.11.2021
Karger Publishers
Subjects
acute myeloid leukemia
Autopsies
autopsy
Bone marrow
Case Report
Case reports
chronic lymphocytic leukemia
Cloning
Flow cytometry
Genotype & phenotype
immunohistochemical staining
Laboratories
Leukemia
Liver
Lymphocytes
Patients
Spleen
Stains & staining
Tomography
Flow cytometry
Chronic lymphocytic leukemia
Immunohistochemical staining
Autopsy
Acute myeloid leukemia
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Summary:Abstract The concurrent onset of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) is rare, and no autopsy case has been reported. We report herein the first case of concurrent-onset CLL and AML with an atypical phenotype revealed by autopsy. Notably, the diagnosis of AML was quite difficult during the patient’s lifetime because of the atypical phenotype. However, autopsy revealed that the patient’s bone marrow, liver, and spleen were filled with myeloblasts. In addition, p53 stain and PCR of IgH rearrangement using the autopsy specimen suggested that CLL and AML might be different clones. In conclusion, our case highlights the importance of considering synchronous complications of AML in CLL patients, particularly in those with an atypical clinical course.
ISSN:1662-6575
1662-6575
DOI:10.1159/000520427