Glaucoma and Antioxidants: Review and Update

Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to as...

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Published inAntioxidants Vol. 9; no. 11; p. 1031
Main Authors Garcia-Medina, Jose Javier, Rubio-Velazquez, Elena, Lopez-Bernal, Maria Dolores, Cobo-Martinez, Alejandro, Zanon-Moreno, Vicente, Pinazo-Duran, Maria Dolores, del-Rio-Vellosillo, Monica
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 22.10.2020
MDPI
Subjects
Acids
Animal models
antioxidant
Antioxidants
Apoptosis
Cell death
Clinical trials
Glaucoma
Ischemia
Lipid peroxidation
Lipids
Neurodegeneration
Neurodegenerative diseases
Optic nerve
Oxidative stress
Pathophysiology
Physiological aspects
Retinal ganglion cells
Review
Supplements
Vitamin C
Vitamin E
Spain
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Summary:Glaucoma is a neurodegenerative disease characterised by the progressive degeneration of retinal ganglion cells. Oxidative stress has been related to the cell death in this disease. Theoretically, this deleterious consequence can be reduced by antioxidants substances. The aim of this review is to assemble the studies published in relation to antioxidant supplementation and its effects on glaucoma and to offer the reader an update on this field. With this purpose, we have included studies in animal models of glaucoma and clinical trials. Although there are variable results, supplementation with antioxidants in glaucoma may be a promising therapy in glaucoma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
M.D.P.-D. and M.d.R.-V. share the last authorship.
J.J.G.-M., E.R.-V and M.D.L.-B. share the first authorship.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9111031