Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential -19.7 mV. Both trans...

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Published inPlants (Basel) Vol. 12; no. 15; p. 2813
Main Authors Abdelgawad, Fatma Alzahra M, El-Hawary, Seham S, Abd El-Kader, Essam M, Alshehri, Saad Ali, Rabeh, Mohamed Abdelaaty, El-Mosallamy, Aliaa E M K, El Raey, Mohamed A, El Gedaily, Rania A
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.07.2023
MDPI
Subjects
Antiviral activity
Antiviral agents
Biosynthesis
Caffeic acid
Cancer
Chlorogenic acid
Composition
Control
coronavirus 6
Coronaviruses
Coumaric acid
Cytotoxicity
Design and construction
Dihydroxybenzoic acid
Ellagic acid
Ferulic acid
Gallic acid
green synthesis 4
Health aspects
Ions
Kaempferol
LC-MS2
Maesa indica
Maesa indica 5
Materia medica, Vegetable
Metabolites
MRM 3
Nanoparticles
Naringenin
Phenolic compounds
Phenols
Physiological aspects
Phytochemicals
Plant extracts
Quercetin
Rutin
Secondary metabolites
sustainable 1
Testing
Transmission electron microscopy
Vanillin
Viruses
X-ray diffraction
Zeta potential
Zinc oxide
Egypt
LC-MS2
MRM 3
green synthesis 4
coronavirus 6
sustainable 1
Maesa indica 5
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Abstract Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential -19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC ) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC ) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from . More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
AbstractList Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC[sub.50] ) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC[sub.50] ) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica. More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential -19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC ) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC ) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from . More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC 50 ) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC 50 ) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica . More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC50) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC50) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica. More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.
Audience Academic
Author El Raey, Mohamed A
El-Hawary, Seham S
Abdelgawad, Fatma Alzahra M
Alshehri, Saad Ali
Abd El-Kader, Essam M
Rabeh, Mohamed Abdelaaty
El-Mosallamy, Aliaa E M K
El Gedaily, Rania A
AuthorAffiliation 1 Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; fatma.mahrous@hu.edu.eg
6 Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, 33 El Bohouth Street, Cairo 12622, Egypt; elraiy@gmail.com
4 Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62251, Saudi Arabia; salshhri@kku.edu.sa (S.A.A.); mrabeh@kku.edu.sa (M.A.R.)
5 Department of Pharmacology, Medical Division, National Research Centre, Cairo 12622, Egypt; aliaamoneer@hotmail.com
2 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Giza 11562, Egypt; seham.elhawary@yahoo.com
3 Department of Timber Trees Research, Horticultural Research Institute (ARC), Giza 12619, Egypt; eltorifi_ola@yahoo.com
AuthorAffiliation_xml – name: 4 Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 62251, Saudi Arabia; salshhri@kku.edu.sa (S.A.A.); mrabeh@kku.edu.sa (M.A.R.)
– name: 1 Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; fatma.mahrous@hu.edu.eg
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37570967$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_2144_fsoa_2023_0196
crossref_primary_10_3389_fmicb_2024_1366614
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Issue 15
Keywords LC-MS2
MRM 3
green synthesis 4
coronavirus 6
sustainable 1
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Snippet Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Roxb. Sweet (ME) aerial parts were used for biosynthesis...
Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for...
Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for...
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StartPage 2813
SubjectTerms Antiviral activity
Antiviral agents
Biosynthesis
Caffeic acid
Cancer
Chlorogenic acid
Composition
Control
coronavirus 6
Coronaviruses
Coumaric acid
Cytotoxicity
Design and construction
Dihydroxybenzoic acid
Ellagic acid
Ferulic acid
Gallic acid
green synthesis 4
Health aspects
Ions
Kaempferol
LC-MS2
Maesa indica
Maesa indica 5
Materia medica, Vegetable
Metabolites
MRM 3
Nanoparticles
Naringenin
Phenolic compounds
Phenols
Physiological aspects
Phytochemicals
Plant extracts
Quercetin
Rutin
Secondary metabolites
sustainable 1
Testing
Transmission electron microscopy
Vanillin
Viruses
X-ray diffraction
Zeta potential
Zinc oxide
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Title Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E
URI https://www.ncbi.nlm.nih.gov/pubmed/37570967
https://www.proquest.com/docview/2849041738
https://search.proquest.com/docview/2850308890
https://pubmed.ncbi.nlm.nih.gov/PMC10420985
https://doaj.org/article/fb761affc1da4f5eb9b37eb8d3c7784b
Volume 12
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