The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression
Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequen...
Saved in:
Published in | Oncogene Vol. 31; no. 46; pp. 4878 - 4887 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
15.11.2012
Nature Publishing Group [1987-....] |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequently overexpressed in human prostate tumours and has an important role in prostate cancer pathogenesis and progression. Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases. Moreover, UHRF1 expression was associated with reduced overall survival after prostatectomy in patients with organ-confined prostate tumours (P < 0.0001). UHRF1 expression was negatively correlated with several tumour suppressor genes and positively with the histone methyltransferase (HMT) EZH2 both in prostate tumours and cell lines. UHRF1 knockdown reduced proliferation, clonogenic capability and anchorage-independent growth of prostate cancer cells. Depletion of UHRF1 resulted in reactivation of several tumour suppressor genes. Gene reactivation upon UHRF1 depletion was associated with changes in histone H3K9 methylation, acetylation and DNA methylation, and impaired binding of the H3K9 HMT Suv39H1 to the promoter of silenced genes. Co-immunoprecipitation experiments showed direct interaction between UHRF1 and Suv39H1. Our data support the notion that UHRF1, along with Suv39H1 and DNA methyltransferases, contributes to epigenetic gene silencing in prostate tumours. This could represent a parallel and convergent pathway to the H3K27 methylation catalyzed by EZH2 to synergistically promote inactivation of tumour suppressor genes. Deregulated expression of UHRF1 is involved in the prostate cancer pathogenesis and might represent a useful marker to distinguish indolent cancer from those at high risk of lethal progression. |
---|---|
AbstractList | Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequently overexpressed in human prostate tumours and has an important role in prostate cancer pathogenesis and progression. Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases. Moreover, UHRF1 expression was associated with reduced overall survival after prostatectomy in patients with organ-confined prostate tumours (P < 0.0001). UHRF1 expression was negatively correlated with several tumour suppressor genes and positively with the histone methyltransferase (HMT) EZH2 both in prostate tumours and cell lines. UHRF1 knockdown reduced proliferation, clonogenic capability and anchorage-independent growth of prostate cancer cells. Depletion of UHRF1 resulted in reactivation of several tumour suppressor genes. Gene reactivation upon UHRF1 depletion was associated with changes in histone H3K9 methylation, acetylation and DNA methylation, and impaired binding of the H3K9 HMT Suv39H1 to the promoter of silenced genes. Co-immunoprecipitation experiments showed direct interaction between UHRF1 and Suv39H1. Our data support the notion that UHRF1, along with Suv39H1 and DNA methyltransferases, contributes to epigenetic gene silencing in prostate tumours. This could represent a parallel and convergent pathway to the H3K27 methylation catalyzed by EZH2 to synergistically promote inactivation of tumour suppressor genes. Deregulated expression of UHRF1 is involved in the prostate cancer pathogenesis and might represent a useful marker to distinguish indolent cancer from those at high risk of lethal progression. Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequently overexpressed in human prostate tumours and has an important role in prostate cancer pathogenesis and progression. Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases. Moreover, UHRF1 expression was associated with reduced overall survival after prostatectomy in patients with organ-confined prostate tumours (P<0.0001). UHRF1 expression was negatively correlated with several tumour suppressor genes and positively with the histone methyltransferase (HMT) EZH2 both in prostate tumours and cell lines. UHRF1 knockdown reduced proliferation, clonogenic capability and anchorage-independent growth of prostate cancer cells. Depletion of UHRF1 resulted in reactivation of several tumour suppressor genes. Gene reactivation upon UHRF1 depletion was associated with changes in histone H3K9 methylation, acetylation and DNA methylation, and impaired binding of the H3K9 HMT Suv39H1 to the promoter of silenced genes. Co-immunoprecipitation experiments showed direct interaction between UHRF1 and Suv39H1. Our data support the notion that UHRF1, along with Suv39H1 and DNA methyltransferases, contributes to epigenetic gene silencing in prostate tumours. This could represent a parallel and convergent pathway to the H3K27 methylation catalyzed by EZH2 to synergistically promote inactivation of tumour suppressor genes. Deregulated expression of UHRF1 is involved in the prostate cancer pathogenesis and might represent a useful marker to distinguish indolent cancer from those at high risk of lethal progression. [PUBLICATION ABSTRACT] Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and RING-finger-associated domain-containing protein UHRF1 might be an important link between different epigenetic pathways. Here, we report that UHRF1 is frequently overexpressed in human prostate tumours and has an important role in prostate cancer pathogenesis and progression. Analysis of human prostate cancer samples by microarrays and immunohistochemistry showed increased expression of UHRF1 in about half of the cases. Moreover, UHRF1 expression was associated with reduced overall survival after prostatectomy in patients with organ-confined prostate tumours (P < 0.0001). UHRF1 expression was negatively correlated with several tumour suppressor genes and positively with the histone methyltransferase (HMT) EZH2 both in prostate tumours and cell lines. UHRF1 knockdown reduced proliferation, clonogenic capability and anchorage-independent growth of prostate cancer cells. Depletion of UHRF1 resulted in reactivation of several tumour suppressor genes. Gene reactivation upon UHRF1 depletion was associated with changes in histone H3K9 methylation, acetylation and DNA methylation, and impaired binding of the H3K9 HMT Suv39H1 to the promoter of silenced genes. Co-immunoprecipitation experiments showed direct interaction between UHRF1 and Suv39H1. Our data support the notion that UHRF1, along with Suv39H1 and DNA methyltransferases, contributes to epigenetic gene silencing in prostate tumours. This could represent a parallel and convergent pathway to the H3K27 methylation catalyzed by EZH2 to synergistically promote inactivation of tumour suppressor genes. Deregulated expression of UHRF1 is involved in the prostate cancer pathogenesis and might represent a useful marker to distinguish indolent cancer from those at high risk of lethal progression. Keywords: prostate cancer; epigenetics; UHRF1; EZH2; Suv39H1 |
Audience | Academic |
Author | Curti, L Babbio, F Bonapace, I M Chiorino, G Roggero, E Catapano, C V Kunderfranco, P Pinton, S Oudet, P Mello-Grand, M Thalman, G N Castiglioni, I Seiler, R Sarti, M Carbone, G M Pistore, C Brino, L |
Author_xml | – sequence: 1 givenname: F surname: Babbio fullname: Babbio, F organization: Department of Structural and Functional Biology, University of Insubria, Via A da Giussano 12, Busto Arsizio, Italy – sequence: 2 givenname: C surname: Pistore fullname: Pistore, C – sequence: 3 givenname: L surname: Curti fullname: Curti, L – sequence: 4 givenname: I surname: Castiglioni fullname: Castiglioni, I – sequence: 5 givenname: P surname: Kunderfranco fullname: Kunderfranco, P – sequence: 6 givenname: L surname: Brino fullname: Brino, L – sequence: 7 givenname: P surname: Oudet fullname: Oudet, P – sequence: 8 givenname: R surname: Seiler fullname: Seiler, R – sequence: 9 givenname: G N surname: Thalman fullname: Thalman, G N – sequence: 10 givenname: E surname: Roggero fullname: Roggero, E – sequence: 11 givenname: M surname: Sarti fullname: Sarti, M – sequence: 12 givenname: S surname: Pinton fullname: Pinton, S – sequence: 13 givenname: M surname: Mello-Grand fullname: Mello-Grand, M – sequence: 14 givenname: G surname: Chiorino fullname: Chiorino, G – sequence: 15 givenname: C V surname: Catapano fullname: Catapano, C V – sequence: 16 givenname: G M surname: Carbone fullname: Carbone, G M – sequence: 17 givenname: I M surname: Bonapace fullname: Bonapace, I M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22330138$$D View this record in MEDLINE/PubMed https://hal.science/hal-04354738$$DView record in HAL |
BookMark | eNqNkkFv1DAQhS1URLeFG2cUiUuRyDJjx0l8XFWURVoJqbRny3EmW5fEXuLsSvx7HLYUgRBCPtgz_p499rwzduKDJ8ZeIiwRRP0ueLvkgLgsC3zCFlhUZS6lKk7YApSEXHHBT9lZjPcAUCngz9gp50IAinrB7M0dZZ-vV9luDBM5n92ur69wjoYUx4x2bkueJmczO4YYJ9N_iZnxbeZi5vwh9AdKaz8r0uZEmTXe0jjH25FidME_Z08700d68TCfs9ur9zeX63zz6cPHy9Umt1LyKRcWsKWy4wqNUCBbpcpKmVZ2RFQbMpzLrutKUSNiAxZMg0oJ0ZTYVE3Kn7M3x3PvTK93oxvM-E0H4_R6tdFzDgohi0rUB0zsxZFNdX7dU5z04KKlvjeewj5q5LKqRCHUf6BYYV2D5DP6-g_0PuxHnx6teWqPxAJq-S8KE6NkKXn1i9qanrTzXZhGY-er9UogoISynKnlX6g0WhqcTU7pXMr_Jnh7FPxo50jd408h6NlQOhlKz4bSqeKEv3qodd8M1D7CPx0kvgNMIsOS |
CODEN | ONCNES |
CitedBy_id | crossref_primary_10_3389_fonc_2022_981226 crossref_primary_10_1021_pr401188r crossref_primary_10_1016_j_bbalip_2015_02_014 crossref_primary_10_1096_fj_13_233387 crossref_primary_10_1093_jas_skaa205 crossref_primary_10_14348_molcells_2021_0001 crossref_primary_10_1021_acs_biochem_1c00698 crossref_primary_10_1002_mog2_59 crossref_primary_10_1093_nar_gku1350 crossref_primary_10_1080_15384101_2017_1403686 crossref_primary_10_1186_s13046_016_0308_0 crossref_primary_10_3390_biom11020247 crossref_primary_10_1016_j_canlet_2021_07_012 crossref_primary_10_18632_oncotarget_26889 crossref_primary_10_1038_onc_2012_406 crossref_primary_10_1111_cas_12689 crossref_primary_10_1101_gad_284992_116 crossref_primary_10_3390_epigenomes8030026 crossref_primary_10_1016_j_jff_2018_03_013 crossref_primary_10_1038_s41374_018_0104_x crossref_primary_10_1172_JCI96121 crossref_primary_10_3892_or_2014_3145 crossref_primary_10_18632_aging_202600 crossref_primary_10_1038_s41598_024_62508_y crossref_primary_10_1038_ncomms15622 crossref_primary_10_1002_cmdc_201700177 crossref_primary_10_1016_j_bbagrm_2014_02_007 crossref_primary_10_1007_s13277_015_3638_1 crossref_primary_10_1016_j_celrep_2016_03_016 crossref_primary_10_1016_j_neures_2018_05_007 crossref_primary_10_1186_s13148_019_0668_3 crossref_primary_10_3390_ijms18061179 crossref_primary_10_1016_j_biocel_2019_06_006 crossref_primary_10_1016_j_bbagrm_2018_02_006 crossref_primary_10_1038_s41388_019_0822_6 crossref_primary_10_1016_j_biocel_2024_106582 crossref_primary_10_18632_oncotarget_12310 crossref_primary_10_18632_oncotarget_11067 crossref_primary_10_18632_oncotarget_17393 crossref_primary_10_1016_j_bbrc_2015_07_131 crossref_primary_10_18632_oncotarget_3297 crossref_primary_10_1074_mcp_M115_057448 crossref_primary_10_1038_s41467_023_39591_2 crossref_primary_10_3390_genes12050622 crossref_primary_10_1002_path_4665 crossref_primary_10_1016_j_cell_2022_06_052 crossref_primary_10_1007_s11010_014_2279_9 crossref_primary_10_3389_fonc_2019_00489 crossref_primary_10_18632_oncotarget_10887 crossref_primary_10_1186_s13148_021_01007_7 crossref_primary_10_1053_j_gastro_2013_01_058 crossref_primary_10_1016_j_isci_2022_104196 crossref_primary_10_1038_celldisc_2016_7 crossref_primary_10_1080_15384047_2015_1056411 crossref_primary_10_1093_nar_gkab293 crossref_primary_10_1016_j_bbrc_2020_03_185 crossref_primary_10_3892_ol_2017_7290 crossref_primary_10_1091_mbc_e13_12_0733 crossref_primary_10_1530_ERC_13_0070 crossref_primary_10_1111_jcmm_15438 crossref_primary_10_1038_onc_2017_159 crossref_primary_10_1038_onc_2012_3 crossref_primary_10_1111_febs_13502 crossref_primary_10_1074_jbc_M112_415398 crossref_primary_10_1038_s41389_022_00446_y crossref_primary_10_3390_ijms20122991 crossref_primary_10_1016_j_gene_2015_05_073 crossref_primary_10_1155_2019_9456847 crossref_primary_10_1186_s13059_015_0699_9 crossref_primary_10_3390_molecules28165997 crossref_primary_10_3390_molecules25040979 crossref_primary_10_1093_nar_gkv183 crossref_primary_10_1111_1751_2980_12329 crossref_primary_10_1002_prot_26278 crossref_primary_10_18632_oncotarget_25425 crossref_primary_10_2217_epi_12_27 crossref_primary_10_1038_s41467_023_37064_0 crossref_primary_10_1016_j_tiv_2016_12_007 crossref_primary_10_1007_s12032_016_0799_8 crossref_primary_10_1515_med_2023_0650 crossref_primary_10_1016_j_ccr_2014_01_003 crossref_primary_10_1007_s12032_013_0613_9 crossref_primary_10_3892_mmr_2015_4515 crossref_primary_10_1038_s41388_019_1032_y crossref_primary_10_1038_s41388_023_02911_3 crossref_primary_10_1177_1010428317692205 crossref_primary_10_1371_journal_pone_0104252 crossref_primary_10_1039_C7FO00263G crossref_primary_10_3389_fimmu_2022_942465 crossref_primary_10_1007_s12017_013_8254_x crossref_primary_10_26508_lsa_202101114 crossref_primary_10_3390_cancers14174262 crossref_primary_10_1016_j_bcp_2023_115489 crossref_primary_10_3389_fonc_2020_00134 crossref_primary_10_1074_jbc_M113_476606 crossref_primary_10_1038_emm_2017_11 crossref_primary_10_1073_pnas_1500992113 crossref_primary_10_3109_1354750X_2015_1061599 |
Cites_doi | 10.1038/sj.bjc.6605123 10.1038/sj.onc.1210953 10.1038/nature01075 10.1158/0008-5472.CAN-07-2498 10.1158/1078-0432.CCR-03-0643 10.1038/ncb2023 10.1093/nar/gkn961 10.1128/MCB.22.15.5539-5553.2002 10.1016/j.molcel.2009.10.009 10.1158/0008-5472.CAN-08-0695 10.1038/emboj.2009.139 10.1016/j.eururo.2011.06.035 10.1038/embor.2009.201 10.1097/01.ju.0000176796.47988.64 10.1038/nature06397 10.1371/journal.pone.0010547 10.1038/nature04020 10.1093/nar/gkp991 10.1371/journal.pone.0002037 10.1128/MCB.00323-08 10.1038/70602 10.1196/annals.1339.018 10.1093/nar/gkf593 10.1016/j.semcancer.2004.06.005 10.1016/j.eururo.2006.11.020 10.1371/journal.pone.0013732 10.1038/sj.onc.1208053 10.1371/journal.pbio.0030044 10.1016/j.eururo.2006.08.008 10.1091/mbc.e07-10-1059 10.1074/jbc.M800224200 10.1371/journal.pone.0004687 10.1083/jcb.200201025 10.1016/S0092-8674(01)00542-6 10.1038/sj.onc.1210248 10.1021/bi100213t 10.1200/JCO.2005.01.5180 10.1126/science.1147939 10.1038/onc.2008.333 10.1074/jbc.M109.098301 10.1128/MCB.24.6.2526-2535.2004 10.1038/sj.bjc.6604976 10.1038/ng.159 10.1158/0008-5472.CAN-04-2938 10.1091/mbc.e06-09-0874 10.1038/nrurol.2010.185 10.1038/ncb1546 10.1016/j.cdp.2007.09.002 10.1200/JCO.2008.18.2485 10.1016/j.bcp.2009.05.035 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2012 Nature Publishing Group Copyright Nature Publishing Group Nov 15, 2012 Macmillan Publishers Limited 2012. Distributed under a Creative Commons Attribution 4.0 International License |
Copyright_xml | – notice: COPYRIGHT 2012 Nature Publishing Group – notice: Copyright Nature Publishing Group Nov 15, 2012 – notice: Macmillan Publishers Limited 2012. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PQEST PQQKQ PQUKI PRINS Q9U RC3 7X8 1XC |
DOI | 10.1038/onc.2011.641 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Research Library Prep Research Library Prep Genetics Abstracts MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Biology |
EISSN | 1476-5594 |
EndPage | 4887 |
ExternalDocumentID | oai_HAL_hal_04354738v1 2815982281 A310150667 10_1038_onc_2011_641 22330138 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Italy Switzerland |
GeographicLocations_xml | – name: Switzerland – name: Italy |
GroupedDBID | --- -Q- 0R~ 123 29N 2WC 36B 39C 3O- 3V. 4.4 406 53G 5RE 70F 7X7 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AANZL AATNV AAWBL AAZLF ABAKF ABAWZ ABDBF ABJNI ABLJU ABUWG ABZZP ACAOD ACBMV ACBRV ACBYP ACGFO ACGFS ACIGE ACKTT ACMJI ACPRK ACRQY ACTTH ACVWB ACZOJ ADBBV ADFRT ADHDB ADMDM ADYYL AEFTE AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFNRJ AFSHS AGEZK AGGBP AGHAI AGQEE AHMBA AHSBF AILAN AJCLW AJDOV AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMYLF ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CGR CS3 CUY CVF DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS ECM EE. EIF EIOEI EJD EMB EMK EMOBN EPL ESX F5P FDQFY FEDTE FERAY FIZPM FRP FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR ITC IWAJR JSO JZLTJ KQ8 L7B LK8 M0L M1P M2O M7P N9A NAO NPM NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO Q2X RNT RNTTT SNX SNYQT SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TSG TUS UKHRP W2D WH7 ZA5 ~8M AAYXX ALIPV CITATION NXXTH AADWK AAYFA AAYJO ABGIJ ADQMX AEDAW AMRJV NYICJ FIGPU 7TM 7TO 7U9 7XB 8FD 8FK FR3 H94 K9. MBDVC P64 PQEST PQUKI PRINS Q9U RC3 7X8 .55 .GJ 1XC AACDK AASML ABEFU AEFQL AFFNX AIGIU BAWUL CAG COF LGEZI LOTEE NADUK RNS TR2 UDS X7M ZXP |
ID | FETCH-LOGICAL-c552t-3c01de6f291a3905d99679ad5feee8aea225fff638111b0c0ab19933b61b7bf63 |
IEDL.DBID | 8C1 |
ISSN | 0950-9232 |
IngestDate | Fri Aug 30 06:30:17 EDT 2024 Fri Aug 16 01:26:27 EDT 2024 Fri Aug 16 05:54:03 EDT 2024 Fri Sep 13 08:38:40 EDT 2024 Fri Sep 13 07:49:23 EDT 2024 Thu Feb 22 23:29:20 EST 2024 Fri Feb 02 04:26:16 EST 2024 Fri Aug 23 01:51:08 EDT 2024 Thu May 23 23:46:31 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 46 |
Language | English |
License | Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c552t-3c01de6f291a3905d99679ad5feee8aea225fff638111b0c0ab19933b61b7bf63 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
OpenAccessLink | https://www.nature.com/articles/onc2011641.pdf |
PMID | 22330138 |
PQID | 1151956527 |
PQPubID | 36330 |
PageCount | 10 |
ParticipantIDs | hal_primary_oai_HAL_hal_04354738v1 proquest_miscellaneous_1257734391 proquest_miscellaneous_1171880521 proquest_journals_2641514085 proquest_journals_1151956527 gale_infotracmisc_A310150667 gale_infotracacademiconefile_A310150667 crossref_primary_10_1038_onc_2011_641 pubmed_primary_22330138 |
PublicationCentury | 2000 |
PublicationDate | 2012-11-15 |
PublicationDateYYYYMMDD | 2012-11-15 |
PublicationDate_xml | – month: 11 year: 2012 text: 2012-11-15 day: 15 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: New York |
PublicationTitle | Oncogene |
PublicationTitleAlternate | Oncogene |
PublicationYear | 2012 |
Publisher | Nature Publishing Group Nature Publishing Group [1987-....] |
Publisher_xml | – name: Nature Publishing Group – name: Nature Publishing Group [1987-....] |
References | Y Kondo (BFonc2011641_CR22) 2008; 3 M Unoki (BFonc2011641_CR20) 2009; 78 M Wissmann (BFonc2011641_CR8) 2007; 9 J van der Vlag (BFonc2011641_CR45) 1999; 23 GJ van Leenders (BFonc2011641_CR6) 2007; 52 C Jeronimo (BFonc2011641_CR3) 2011; 60 M Unoki (BFonc2011641_CR17) 2004; 23 S Fujii (BFonc2011641_CR28) 2008; 283 A Prtilo (BFonc2011641_CR46) 2005; 174 IM Bachmann (BFonc2011641_CR5) 2006; 24 P Pallante (BFonc2011641_CR31) 2008; 68 D Meilinger (BFonc2011641_CR14) 2009; 10 SA Abdulkadir (BFonc2011641_CR37) 2005; 1059 E Citterio (BFonc2011641_CR19) 2004; 24 R Papait (BFonc2011641_CR13) 2007; 18 Q Li (BFonc2011641_CR44) 2010; 5 IM Bonapace (BFonc2011641_CR15) 2002; 157 J Sharif (BFonc2011641_CR11) 2007; 450 M Unoki (BFonc2011641_CR21) 2009; 101 X Cheng (BFonc2011641_CR42) 2010; 49 L Beke (BFonc2011641_CR26) 2007; 26 T Raha (BFonc2011641_CR50) 2005; 3 TD Chuang (BFonc2011641_CR34) 2010; 285 S Napoli (BFonc2011641_CR49) 2009; 28 J Yu (BFonc2011641_CR23) 2007; 67 YJ Yang (BFonc2011641_CR40) 2010; 38 E Metzger (BFonc2011641_CR9) 2005; 437 AS Perry (BFonc2011641_CR2) 2010; 7 M Bostick (BFonc2011641_CR12) 2007; 317 Q Cao (BFonc2011641_CR29) 2008; 27 MW Coolen (BFonc2011641_CR10) 2010; 12 AP Feinberg (BFonc2011641_CR1) 2004; 14 R Berger (BFonc2011641_CR48) 2004; 64 RK Palakurthy (BFonc2011641_CR27) 2009; 36 P Kunderfranco (BFonc2011641_CR7) 2010; 5 AH Peters (BFonc2011641_CR38) 2001; 107 S Varambally (BFonc2011641_CR4) 2002; 419 R Cangemi (BFonc2011641_CR47) 2008; 27 C Jeronimo (BFonc2011641_CR32) 2004; 10 Y Kawano (BFonc2011641_CR33) 2009; 100 JK Kim (BFonc2011641_CR16) 2008; 37 XS Ke (BFonc2011641_CR41) 2009; 4 PJ Bastian (BFonc2011641_CR35) 2007; 51 R Papait (BFonc2011641_CR18) 2008; 19 JY Park (BFonc2011641_CR36) 2007; 31 L Richiardi (BFonc2011641_CR30) 2009; 27 RG Sewalt (BFonc2011641_CR43) 2002; 22 Y Kondo (BFonc2011641_CR25) 2008; 40 S Koizume (BFonc2011641_CR39) 2002; 30 N Herranz (BFonc2011641_CR24) 2008; 28 |
References_xml | – volume: 101 start-page: 98 year: 2009 ident: BFonc2011641_CR21 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605123 contributor: fullname: M Unoki – volume: 27 start-page: 2877 year: 2008 ident: BFonc2011641_CR47 publication-title: Oncogene doi: 10.1038/sj.onc.1210953 contributor: fullname: R Cangemi – volume: 419 start-page: 624 year: 2002 ident: BFonc2011641_CR4 publication-title: Nature doi: 10.1038/nature01075 contributor: fullname: S Varambally – volume: 67 start-page: 10657 year: 2007 ident: BFonc2011641_CR23 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-2498 contributor: fullname: J Yu – volume: 10 start-page: 4010 year: 2004 ident: BFonc2011641_CR32 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-03-0643 contributor: fullname: C Jeronimo – volume: 12 start-page: 235 year: 2010 ident: BFonc2011641_CR10 publication-title: Nat Cell Biol doi: 10.1038/ncb2023 contributor: fullname: MW Coolen – volume: 37 start-page: 493 year: 2008 ident: BFonc2011641_CR16 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn961 contributor: fullname: JK Kim – volume: 22 start-page: 5539 year: 2002 ident: BFonc2011641_CR43 publication-title: Mol Cell Biol doi: 10.1128/MCB.22.15.5539-5553.2002 contributor: fullname: RG Sewalt – volume: 36 start-page: 219 year: 2009 ident: BFonc2011641_CR27 publication-title: Mol Cell doi: 10.1016/j.molcel.2009.10.009 contributor: fullname: RK Palakurthy – volume: 68 start-page: 6770 year: 2008 ident: BFonc2011641_CR31 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-0695 contributor: fullname: P Pallante – volume: 28 start-page: 1708 year: 2009 ident: BFonc2011641_CR49 publication-title: EMBO J doi: 10.1038/emboj.2009.139 contributor: fullname: S Napoli – volume: 60 start-page: 753 year: 2011 ident: BFonc2011641_CR3 publication-title: Eur Urol doi: 10.1016/j.eururo.2011.06.035 contributor: fullname: C Jeronimo – volume: 10 start-page: 1259 year: 2009 ident: BFonc2011641_CR14 publication-title: EMBO Rep doi: 10.1038/embor.2009.201 contributor: fullname: D Meilinger – volume: 174 start-page: 1814 year: 2005 ident: BFonc2011641_CR46 publication-title: J Urol doi: 10.1097/01.ju.0000176796.47988.64 contributor: fullname: A Prtilo – volume: 450 start-page: 908 year: 2007 ident: BFonc2011641_CR11 publication-title: Nature doi: 10.1038/nature06397 contributor: fullname: J Sharif – volume: 5 start-page: e10547 year: 2010 ident: BFonc2011641_CR7 publication-title: PLoS One doi: 10.1371/journal.pone.0010547 contributor: fullname: P Kunderfranco – volume: 437 start-page: 436 year: 2005 ident: BFonc2011641_CR9 publication-title: Nature doi: 10.1038/nature04020 contributor: fullname: E Metzger – volume: 38 start-page: 382 year: 2010 ident: BFonc2011641_CR40 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp991 contributor: fullname: YJ Yang – volume: 3 start-page: e2037 year: 2008 ident: BFonc2011641_CR22 publication-title: PLoS ONE doi: 10.1371/journal.pone.0002037 contributor: fullname: Y Kondo – volume: 28 start-page: 4772 year: 2008 ident: BFonc2011641_CR24 publication-title: Mol Cell Biol doi: 10.1128/MCB.00323-08 contributor: fullname: N Herranz – volume: 23 start-page: 474 year: 1999 ident: BFonc2011641_CR45 publication-title: Nat Genet doi: 10.1038/70602 contributor: fullname: J van der Vlag – volume: 1059 start-page: 33 year: 2005 ident: BFonc2011641_CR37 publication-title: Ann NY Acad Sci doi: 10.1196/annals.1339.018 contributor: fullname: SA Abdulkadir – volume: 30 start-page: 4770 year: 2002 ident: BFonc2011641_CR39 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkf593 contributor: fullname: S Koizume – volume: 14 start-page: 427 year: 2004 ident: BFonc2011641_CR1 publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2004.06.005 contributor: fullname: AP Feinberg – volume: 52 start-page: 455 year: 2007 ident: BFonc2011641_CR6 publication-title: Eur Urol doi: 10.1016/j.eururo.2006.11.020 contributor: fullname: GJ van Leenders – volume: 5 start-page: e13732 year: 2010 ident: BFonc2011641_CR44 publication-title: PLoS One doi: 10.1371/journal.pone.0013732 contributor: fullname: Q Li – volume: 23 start-page: 7601 year: 2004 ident: BFonc2011641_CR17 publication-title: Oncogene doi: 10.1038/sj.onc.1208053 contributor: fullname: M Unoki – volume: 3 start-page: e44 year: 2005 ident: BFonc2011641_CR50 publication-title: PLoS Biol doi: 10.1371/journal.pbio.0030044 contributor: fullname: T Raha – volume: 51 start-page: 665 year: 2007 ident: BFonc2011641_CR35 publication-title: Eur Urol doi: 10.1016/j.eururo.2006.08.008 contributor: fullname: PJ Bastian – volume: 19 start-page: 3554 year: 2008 ident: BFonc2011641_CR18 publication-title: Mol Biol Cell doi: 10.1091/mbc.e07-10-1059 contributor: fullname: R Papait – volume: 283 start-page: 17324 year: 2008 ident: BFonc2011641_CR28 publication-title: J Biol Chem doi: 10.1074/jbc.M800224200 contributor: fullname: S Fujii – volume: 4 start-page: e4687 year: 2009 ident: BFonc2011641_CR41 publication-title: PLoS One doi: 10.1371/journal.pone.0004687 contributor: fullname: XS Ke – volume: 157 start-page: 909 year: 2002 ident: BFonc2011641_CR15 publication-title: J Cell Biol doi: 10.1083/jcb.200201025 contributor: fullname: IM Bonapace – volume: 107 start-page: 323 year: 2001 ident: BFonc2011641_CR38 publication-title: Cell doi: 10.1016/S0092-8674(01)00542-6 contributor: fullname: AH Peters – volume: 26 start-page: 4590 year: 2007 ident: BFonc2011641_CR26 publication-title: Oncogene doi: 10.1038/sj.onc.1210248 contributor: fullname: L Beke – volume: 49 start-page: 2999 year: 2010 ident: BFonc2011641_CR42 publication-title: Biochemistry doi: 10.1021/bi100213t contributor: fullname: X Cheng – volume: 24 start-page: 268 year: 2006 ident: BFonc2011641_CR5 publication-title: J Clin Oncol doi: 10.1200/JCO.2005.01.5180 contributor: fullname: IM Bachmann – volume: 317 start-page: 1760 year: 2007 ident: BFonc2011641_CR12 publication-title: Science doi: 10.1126/science.1147939 contributor: fullname: M Bostick – volume: 27 start-page: 7274 year: 2008 ident: BFonc2011641_CR29 publication-title: Oncogene doi: 10.1038/onc.2008.333 contributor: fullname: Q Cao – volume: 285 start-page: 23598 year: 2010 ident: BFonc2011641_CR34 publication-title: J Biol Chem doi: 10.1074/jbc.M109.098301 contributor: fullname: TD Chuang – volume: 24 start-page: 2526 year: 2004 ident: BFonc2011641_CR19 publication-title: Mol Cell Biol doi: 10.1128/MCB.24.6.2526-2535.2004 contributor: fullname: E Citterio – volume: 100 start-page: 1165 year: 2009 ident: BFonc2011641_CR33 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604976 contributor: fullname: Y Kawano – volume: 40 start-page: 741 year: 2008 ident: BFonc2011641_CR25 publication-title: Nat Genet doi: 10.1038/ng.159 contributor: fullname: Y Kondo – volume: 64 start-page: 8867 year: 2004 ident: BFonc2011641_CR48 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2938 contributor: fullname: R Berger – volume: 18 start-page: 1098 year: 2007 ident: BFonc2011641_CR13 publication-title: Mol Biol Cell doi: 10.1091/mbc.e06-09-0874 contributor: fullname: R Papait – volume: 7 start-page: 668 year: 2010 ident: BFonc2011641_CR2 publication-title: Nat Rev Urol doi: 10.1038/nrurol.2010.185 contributor: fullname: AS Perry – volume: 9 start-page: 347 year: 2007 ident: BFonc2011641_CR8 publication-title: Nat Cell Biol doi: 10.1038/ncb1546 contributor: fullname: M Wissmann – volume: 31 start-page: 359 year: 2007 ident: BFonc2011641_CR36 publication-title: Cancer Detect Prev doi: 10.1016/j.cdp.2007.09.002 contributor: fullname: JY Park – volume: 27 start-page: 3161 year: 2009 ident: BFonc2011641_CR30 publication-title: J Clin Oncol doi: 10.1200/JCO.2008.18.2485 contributor: fullname: L Richiardi – volume: 78 start-page: 1279 year: 2009 ident: BFonc2011641_CR20 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2009.05.035 contributor: fullname: M Unoki |
SSID | ssj0007902 |
Score | 2.4257722 |
Snippet | Epigenetic silencing of tumour suppressor genes is an important mechanism involved in cell transformation and tumour progression. The Set and... |
SourceID | hal proquest gale crossref pubmed |
SourceType | Open Access Repository Aggregation Database Index Database |
StartPage | 4878 |
SubjectTerms | Acetylation Analysis Biochemistry, Molecular Biology CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Growth Processes - physiology Cell Line, Tumor Cell proliferation Cellular biology Cellular proteins Data processing Development and progression Disease Progression DNA Methylation DNA methyltransferase DNA microarrays DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Genes Genes, Tumor Suppressor Genetic aspects HEK293 Cells Histone methyltransferase Histone Methyltransferases Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones Histones - genetics Histones - metabolism Humans Immunohistochemistry Immunoprecipitation Immunoprecipitation - methods Life Sciences Male Methylation Pathogenesis Physiological aspects Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Promoter Regions, Genetic Promoters Prostate cancer Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Risk factors Transformation Tumor suppressor genes Tumors |
Title | The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression |
URI | https://www.ncbi.nlm.nih.gov/pubmed/22330138 https://www.proquest.com/docview/1151956527/abstract/ https://www.proquest.com/docview/2641514085/abstract/ https://search.proquest.com/docview/1171880521 https://search.proquest.com/docview/1257734391 https://hal.science/hal-04354738 |
Volume | 31 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swED-alm19GVv25S0L2tjYk4kt2ZbyNLLQYMZaRrZA3oQkyywMnKxJC_vve-ePlEDbN9uSLXF3Ov9s3f0O4FPGreGycKGInAsT5ePQjFURCmO5k8qWrs56P7_I8kXyfZkujyDvcmEorLLzibWjLtaO_pGPELlQaluKn-rG0l8Atxt93fwLqX4U7bO2xTR6cBKjiVIRBzW9DfaQTfQh4okoREjD2xD4SKjRunINk2eWxAcvp9ZF9_5QhOR98LN-Dc2ewdMWP7JJo_DncOSrPjxqKkr-78OTaVfArQ-Pz9t98xfg0BrYr_mE1bQMq4ot8vkspjPUlN8yvyFSTspnZPXMEJH_3TJTFWy1ZasKXdi1x-OK7qhTkJgja7lkdXhXQ-3xEhazs9_TPGzLK4QuTfkuFC6KC5-VfBwbMY7SAj995NgUaem9V8YblGNZlrhA0R_ayEXGUrSfsFlspcXrr-C4Wlf-DTDrvUi4kSp1LnGZM6lSmfKl5xwhRlkG8LmTq940LBq63v0WSqP8Nclfo_wD-EJC17S4SMWmzRHAUYimSk8QjBIlYiYDGBz0RNG6g-aPqLb9WMShnU9-aLoWIUBMpFDXONqg06puV-5W39rZnc2IH7ED0cIF8GHfTKNTsFrl11f0CEksdwiMHuiDrlIKSnsO4HVjUPvZImITtIH89uH5vYNTlBunxMg4HcDx7vLKv0eEtLND6MmlHNZLYAgn384ufs5vAJ5UDy8 |
link.rule.ids | 230,315,786,790,891,12083,12250,21416,27957,27958,31754,31755,33301,33302,33779,33780,43345,43614,43840,74102,74371,74659 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Rb9MwED6xIRgvCAqDQAGDQDxFS-wkdp9QNVEFaPcwVqlvlu04okJKS9NN4t9zl7hFlWBvie3E1tl3_hLffQfwvuDWcFm5WCTOxZnyaWxGqoqFsdxJZWvXRb3PLopynn1d5Ivww60NbpU7m9gZ6mrl6B_5GSIXCm3Lufy0_hVT1ig6XQ0pNI7gbiZERi59crH_4Epk73OIKCKJEcjw4PieCHW2alzP31lk6cGWFAzz0Q_yi_wf6Ow2n8kjeBhQIxv30_wY7vhmAPf6PJK_B3ByvkvbNoD7s3Ba_gQcrgH2_XLMOjKGZcPm5eUkpTucH98yvyYqTopiZN3IEIf_bJlpKrZs2bJBw3Xj8bqhJ7rAI-ZojWxY59TVE3o8hfnk89V5GYekCrHLc76NhUvSyhc1H6VGjJK8wg8eOTJVXnvvlfEGFbyua1RLtII2cYmx5OMnbJFaabH8FI6bVeOfA7Pei4wbqXLnMlc4kytVKF97zhFY1HUEH3Zy1eueO0N3Z95CaZS_JvlrlH8EH0nomlRquzHOhMgA7IXIqfQYISgRIRYyguFBSxStO6h-h9O274uYs8vxVFNZgrAwk0LdYG_D3azqoK-t_ru6_lmNqBEbEBlcBG_31dQ7uag1fnVNr5DEbYdw6JY2aCCloGDnCJ71C2o_WsRpgo6NX9w-vjdwUl7Npnr65eLbS3iAMuQUGpnmQzjebq79K8RIW_u6U4Q_BL4MGQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED6xIQYvCMqvQAGDQDxFS-wkdp9QNagKbBMaVOqbZTu2qJDS0nST-O-5S9yiSrC3JHZi6-w7f47vvgN4U3FruKxdKjLn0kL5PDUjVafCWO6kssF1Ue9n59V0Vnyel_Po_9RGt8qtTewMdb109I_8GJELhbaVuFUP0S3i64fJ-9WvlDJI0UlrTKdxADdxlcwom4Gc7zZfmez9DxFRZCmCGh6d4DOhjpeN67k8qyLfW56ikT74QT6S_wOg3UI0uQd3I4Jk437I78MN3wzgVp9T8vcAbp9sU7gN4Ogsnpw_AIfzgX27GLOOmGHRsNn0YpLTHY6Vb5lfES0nRTSyrmeIyX-2zDQ1W7Rs0aARu_J43dAbXRASczRf1qxz8OrJPR7CbPLx-8k0jQkWUleWfJMKl-W1rwIf5UaMsrLGzY8cmboM3ntlvEFlDyGgiqJFtJnLjCV_P2Gr3EqLzx_BYbNs_BNg1ntRcCNV6VzhKmdKpSrlg-ccQUYICbzdylWveh4N3Z1_C6VR_prkr1H-CbwjoWtSr83aOBOjBLAVIqrSY4SjRIpYyQSGezVRtG6v-DUO264tYtGejk81PcsQIhZSqCtsbbgdVR11t9V_Z9o_ixFBYgUihkvg1a6YWid3tcYvL-kTknjuEBpdUweNpRQU-JzA435C7XqLmE3QEfLT6_v3Eo5QB_Tpp_Mvz-AOipBTlGReDuFws770zxEubeyLTg_-ALWTEEU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+SRA+protein+UHRF1+promotes+epigenetic+crosstalks+and+is+involved+in+prostate+cancer+progression&rft.jtitle=Oncogene&rft.au=Babbio%2C+F&rft.au=Pistore%2C+C&rft.au=Cu&rft.au=Castiglioni%2C+I&rft.date=2012-11-15&rft.pub=Nature+Publishing+Group&rft.issn=0950-9232&rft.eissn=1476-5594&rft.volume=31&rft.issue=46&rft.spage=4878&rft_id=info:doi/10.1038%2Fonc.2011.641&rft.externalDocID=A310150667 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon |