Targeting tumor cell motility to prevent metastasis

Mortality and morbidity in patients with solid tumors invariably result from the disruption of normal biological function caused by disseminating tumor cells. Tumor cell migration is under intense investigation as the underlying cause of cancer metastasis. The need for tumor cell motility in the pro...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 63; no. 8; pp. 568 - 581
Main Authors Palmer, Trenis D., Ashby, William J., Lewis, John D., Zijlstra, Andries
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 18.07.2011
Subjects
Adhesion
Adjuvants
Animals
Cell Adhesion
Cell Communication
Cell Movement - drug effects
Drug Delivery Systems
Humans
Intravasation
Invasion
Metastasis
Migration
Motility
Neoplasm Metastasis - prevention & control
Neoplasms - drug therapy
Neoplasms - pathology
Therapy
Tumor
Therapy
TNFα
Motility
EpCAM
EGF
HGF
VEGF
Migration
SDF-1
Metastasis
Intravasation
EMT
Adhesion
RGD
EphA2
Invasion
MMP
FAK
WAVE
ALCAM
TGFβ
Tumor
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Summary:Mortality and morbidity in patients with solid tumors invariably result from the disruption of normal biological function caused by disseminating tumor cells. Tumor cell migration is under intense investigation as the underlying cause of cancer metastasis. The need for tumor cell motility in the progression of metastasis has been established experimentally and is supported empirically by basic and clinical research implicating a large collection of migration-related genes. However, there are few clinical interventions designed to specifically target the motility of tumor cells and adjuvant therapy to specifically prevent cancer cell dissemination is severely limited. In an attempt to define motility targets suitable for treating metastasis, we have parsed the molecular determinants of tumor cell motility into five underlying principles including cell autonomous ability, soluble communication, cell–cell adhesion, cell–matrix adhesion, and integrating these determinants of migration on molecular scaffolds. The current challenge is to implement meaningful and sustainable inhibition of metastasis by developing clinically viable disruption of molecular targets that control these fundamental capabilities. [Display omitted]
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ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2011.04.008