Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

• Published in: Cell Vol. 141; no. 5; pp. 799 - 811
• Main Authors: Hsu, Nai-Yun, Ilnytska, Olha, Belov, Georgiy, Santiana, Marianita, Chen, Ying-Han, Takvorian, Peter M., Pau, Cyrilla, van der Schaar, Hilde, Kaushik-Basu, Neerja, Balla, Tamas, Cameron, Craig E., Ehrenfeld, Ellie, van Kuppeveld, Frank J.M., Altan-Bonnet, Nihal
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.05.2010
• Subjects: CELLBIO; Coat protein; Endoplasmic Reticulum - metabolism; Enterovirus; Enterovirus - metabolism; Flavivirus - metabolism; HeLa Cells; Humans; MICROBIO; Phosphatidylinositol Phosphates - metabolism; RNA, Viral - metabolism; Secretory Pathway; Virus Replication; CELLBIO; MICROBIO

Many RNA viruses remodel intracellular membranes to generate specialized sites for RNA replication. How membranes are remodeled and what properties make them conducive for replication are unknown. Here we show how RNA viruses can manipulate multiple components of the cellular secretory pathway to ge...