Marine Natural Products. XXXIV. Trisindoline, a New Antibiotic Indole Trimer, Produced by a Bacterium of Vibrio sp. Separated from the Marine Sponge Hyrtios altum

• Published in: Chemical & pharmaceutical bulletin Vol. 42; no. 12; pp. 2449 - 2451
• Main Authors: KOBAYASHI, Motomasa, AOKI, Shunji, GATO, Katsuhiko, MATSUNAMI, Katsuyoshi, KUROSU, Michio, KITAGAWA, Isao
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen; Japan Science and Technology Agency
• Subjects: Animals; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; antibiotic; Bacteria - drug effects; Biological and medical sciences; Chromatography, High Pressure Liquid; General pharmacology; Hydrolysis; Hyrtios altum; indole trimer; Indoles - isolation & purification; Indoles - pharmacology; Magnetic Resonance Spectroscopy; marine sponge; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Porifera - microbiology; trisindoline; Vibrio - growth & development; Vibrio - metabolism; Vibrio sp; Trimer; Pharmacognosy; Lactam; In vitro; Marine environment; Antibiotic; Porifera; Plant origin; Bacteria; Vibrionaceae; Isolation; Invertebrata; Indole derivatives; Chemical synthesis; Structural analysis; Vibrio
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.42.2449

A new antibiotic indole trimer named trisindoline (1) was isolated, together with a known dioxopiperazine brevianamide F (2), from the culture of a bacterium of Vibrio sp., which was separated from the Okinawan marine sponge Hyrtios altum. The structure of trisindoline (1) has been determined on the bases of physicochemical evidence and chemical synthesis.