Application of Agonist-Receptor Modeling to the Sweetness Synergy between High Fructose Corn Syrup and Sucralose, and between High-Potency Sweeteners

• Published in: Journal of food science Vol. 75; no. 2; pp. S95 - S102
• Main Authors: Wolf, P.A, Bridges, J.R, Wicklund, R
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.03.2010; Wiley; Wiley Subscription Services, Inc
• Subjects: acesulfame-K; agonist receptor modeling; agonists; Artificial sweeteners; aspartame; Beverages; binding sites; Biological and medical sciences; Corn; Food additives; Food industries; Food science; Fructose - chemistry; Fructose - metabolism; Fundamental and applied biological sciences. Psychology; General aspects; GPCR; HFCS; high fructose corn syrup; Humans; model food systems; Models, Chemical; sensory properties; sucralose; Sucrose - analogs & derivatives; Sucrose - chemistry; Sucrose - metabolism; Sugar; sweeteners; Sweetening Agents - chemistry; Sweetening Agents - metabolism; sweetness; synergism; synergy; Taste; Agonist; acesulfame-K; synergy; sucralose; sweetness; Food additive; Modeling; Corn syrup; HFCS; Aspartame; Acesulfame; Fructose syrup; GPCR; Sweetener; Models; model; Application
• ISSN: 0022-1147; 1750-3841
• DOI: 10.1111/j.1750-3841.2009.01463.x

The agonist-receptor-transducer model of D. Ennis is applied to beverage formulations sweetened with high fructose corn syrup, sucralose, and other high-potency sweeteners, confirming the utility of the model, and supports the growing volume of evidence for multiple binding sites on the sweetness receptor. The model is further simplified to require less parameters for other sweetener blend systems whenever potency information is available for the single sweeteners.