Transfer of extracellular vesicles during immune cell-cell interactions
Summary The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen‐presenting cells (APCs) has been described, involving exchange of extra...
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Published in | Immunological reviews Vol. 251; no. 1; pp. 125 - 142 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.01.2013
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Subjects | |
Online Access | Get full text |
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Summary: | Summary
The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen‐presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell‐cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell‐cell interactions. |
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Bibliography: | ark:/67375/WNG-07V0B8HL-K ArticleID:IMR12013 istex:E40F4AA2C3E8C7880D123810FCAA91DA50C8B204 Both authors equally contributed to this work. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0105-2896 1600-065X |
DOI: | 10.1111/imr.12013 |