Remarkable Response of Primary Squamous Cell Carcinoma of the Ovary to Paclitaxel and Cisplatin

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 91; no. 5; pp. 844 - 846
• Main Authors: Eltabbakh, Gamal H, Hempling, Ronald E, tRecio, Fernando O.\, O’Neill, Catherine P
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1998; The American College of Obstetricians and Gynecologists; Elsevier Science
• Subjects: Adult; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - secondary; Chemotherapy; Cisplatin - administration & dosage; Combined Modality Therapy; Female; Humans; Liver Neoplasms - secondary; Medical sciences; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Paclitaxel - administration & dosage; Pharmacology. Drug treatments; Tomography, X-Ray Computed; Human; Antineoplastic agent; Drug combination; Squamous cell carcinoma; Radiodiagnosis; Malignant tumor; Survival; Cisplatin; Female genital diseases; Case study; Ovarian diseases; Ovary; Chemotherapy; Primitive; Treatment; Taxane derivatives; Young adult; Paclitaxel; Medical imagery; Female; Computerized axial tomography; Platinum II Complexes
• ISSN: 0029-7844; 1873-233X
• DOI: 10.1016/S0029-7844(97)00665-0

Background: The survival rate of patients with advanced stage primary squamous cell carcinoma of the ovary is dismal and the best treatment is unknown. We describe the response of this tumor to systemic chemotherapy employing paclitaxel and cisplatin. Case: A 31-year-old white woman diagnosed with International Federation of Gynecology and Obstetrics stage IV primary squamous cell carcinoma of the ovary associated with ovarian endometriosis underwent cytoreductive surgery followed by paclitaxel and cisplatin every 4 weeks for 12 courses. The patient tolerated chemotherapy well, demonstrated a dramatic response with disappearance of hepatic metastases, and remains without evidence of disease 2 years after diagnosis. Conclusion: Paclitaxel and cisplatin may be effective in treating primary squamous cell carcinoma of the ovary.