Upconversion Nanoparticles as a Contrast Agent for Photoacoustic Imaging in Live Mice

• Published in: Advanced materials (Weinheim) Vol. 26; no. 32; pp. 5633 - 5638
• Main Authors: Maji, Swarup Kumar, Sreejith, Sivaramapanicker, Joseph, James, Lin, Manjing, He, Tingchao, Tong, Yan, Sun, Handong, Yu, Sidney Wing-Kwong, Zhao, Yanli
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 27.08.2014
• Subjects: alpha-Cyclodextrins - chemistry; Animals; Biomedical materials; Cell Survival - drug effects; contrast agent; Contrast Media - adverse effects; Contrast Media - chemistry; Cyclohexanes - chemistry; Er3; Female; HeLa Cells; Humans; Imaging; In vivo testing; In vivo tests; live mice; Luminescence; Mice; Mice, SCID; Models, Biological; Nanoparticles; Nanoparticles - adverse effects; Nanoparticles - chemistry; NaYF4:Yb3; Phantoms, Imaging; photoacoustic imaging; Photoacoustic Techniques - instrumentation; Photoacoustic Techniques - methods; Quenching; Solvents - chemistry; Tomography - instrumentation; Tomography - methods; Upconversion; upconversion nanoparticles; Water - chemistry; upconversion nanoparticles; live mice; photoacoustic imaging; NaYF4:Yb3; contrast agent; Er3
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201400831

An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α‐cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non‐radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α‐cyclodextrin‐covered NaYF4:Yb3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.