Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers

• Published in: Advanced materials (Weinheim) Vol. 28; no. 6; pp. 1312 - 1318
• Main Authors: Jia, Yi, Duan, Li, Li, Junbai
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 10.02.2016
• Subjects: Adenosine Triphosphate - chemistry; Animals; Antioxidants - chemistry; Assemblies; Blood transfusion; Carriers; Cellular; Cross-Linking Reagents - chemistry; Demand; Erythrocytes - metabolism; Glutathione - chemistry; Hemoglobin; Hemoglobins - chemistry; Humans; layer-by-layer assembly; nanoarchitectonics; Nanoparticles - chemistry; Nanostructure; Nanotechnology - methods; Oxygen - chemistry; oxygen carriers; Pathways; Serum Albumin - chemistry; Solvents - chemistry; oxygen carriers; layer-by-layer assembly; nanoarchitectonics; hemoglobin
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201502581

Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen‐transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen‐carrying unit. With advances in nano‐biotechnology, hemoglobin assemblies as artificial oxygen carriers achieve great development. Here, recent progress on hemoglobin‐based oxygen carriers is highlighted in view of two aspects: acellular hemoglobin‐based oxygen carriers and cellular hemoglobin‐based oxygen carriers. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible oxygen carriers. The development of safe and effective artificial oxygen carriers, which is the subject of much recent interest, is facilitated by the integration of modern nano‐biotechnology and assembly techniques. Recent progress on hemoglobin‐based oxygen carriers is summarized and novel techniques applied are highlighted.