11C-乙酸盐自动化合成改进工艺及PET／CT显像

摘要：采用国产碳-11胆碱／蛋氨酸自动合成模块，研究简单、快速、自动化合成11C-乙酸盐（11C—AC）的T艺流程。11C—CO。与溴化甲基镁（MeMgBr）在改进的Loop环内反应生成中间体乙酰溴化镁加合物，中间体经在柱水解和SEP—PAK小柱纯化后制备”CAC注射液。总合成时间约8min，校正放化产率为（40．5±4．6）％，放化纯度大于95％。该改进法适于多种商用全自动化模块自动化生产11C-AC。生产的11C—AC注射液安全、有效，有望用于动物和人体PET显像研究。...

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Bibliographic Details
Published in同位素 Vol. 26; no. 2; pp. 73 - 78
Main Author 甘满权 唐小兰 唐刚华 王红亮 胡孔珍
Format Journal Article
LanguageChinese
Published 广州医学院第一附属医院PET/CT中心,广州,510230%华南农业大学理学院,广州,510642%中山大学附属第一医院核医学科,广州,510515 2013
Subjects
11C-乙酸盐
PET显像剂
自动化合成
11C-乙酸盐
PET显像剂
自动化合成
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Summary:摘要：采用国产碳-11胆碱／蛋氨酸自动合成模块，研究简单、快速、自动化合成11C-乙酸盐（11C—AC）的T艺流程。11C—CO。与溴化甲基镁（MeMgBr）在改进的Loop环内反应生成中间体乙酰溴化镁加合物，中间体经在柱水解和SEP—PAK小柱纯化后制备”CAC注射液。总合成时间约8min，校正放化产率为（40．5±4．6）％，放化纯度大于95％。该改进法适于多种商用全自动化模块自动化生产11C-AC。生产的11C—AC注射液安全、有效，有望用于动物和人体PET显像研究。
Bibliography:11-2566/TL
GAN Man-quan1 , TANG Xiao-lan2 , TANG Gang-hua3 , WANG Hong-liang3 , HU Kong-zhen：~ （1. PET/ CT Center, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510230, China ; 2. College of Science, Southern China Agricultural University, Guangzhou 510642, China ; 3. Department of Nuclear Medicine, The First Affiliated Hospital , Sun Yat-Sen University, Guangzhou 510515, China）
11 C-acetate; PET imaging agent ; automated synthesis
To study a simple and rapid automated synthetic technology of 11C-acetate （11 C- AC）, automated synthesis of lie-at was performed by carboxylation of MeMgBr/tetra- hydrofuran （THF） on a polyethylene loop with 11C-C（）2, followed by hydrolysis and purifi- cation on solid-phase extraction cartridges using a 11C-Choline/Methionine synthesizer made in China. A high and reproducible radiochemical yield of above 40% （decay corrected） was obtained within the whole synthesis time about 8 rain from i1 C-CO2. The radiochemical pu- rity of 11C-AC was over 950/oo. The novel
ISSN:1000-7512
DOI:10.7538/tws.2013.26.02.0073