Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance

• Published in: Antioxidants Vol. 12; no. 2; p. 485
• Main Authors: Jîtcă, George, Ősz, Bianca E, Vari, Camil E, Rusz, Carmen-Maria, Tero-Vescan, Amelia, Pușcaș, Amalia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Animal cognition; antioxidant; Antioxidants; Cannabidiol; Cannabinoid CB2 receptors; Cannabinoids; Cognitive ability; Diglycerides; Epilepsy; Fatty-acid amide hydrolase; Functional foods & nutraceuticals; Glutathione peroxidase; Glycerol; Health aspects; Inflammation; Kinases; Lipase; Lipoprotein lipase; Marijuana; Mental depression; Neurodegeneration; NF-κB protein; nutraceuticals; oxidative stress; physical activity; Proteins; Review; Romania; cannabidiol; antioxidant; nutraceuticals; oxidative stress; physical activity
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox12020485

The literature provides scientific evidence for the beneficial effects of cannabidiol (CBD), and these effects extend beyond epilepsy treatment (e.g., Lennox-Gastaut and Dravet syndromes), notably the influence on oxidative status, neurodegeneration, cellular protection, cognitive function, and physical performance. However, products containing CBD are not allowed to be marketed everywhere in the world, which may ultimately have a negative effect on health as a result of the uncontrolled CBD market. After the isolation of CBD follows the discovery of CB1 and CB2 receptors and the main enzymatic components (diacylglycerol lipase (DAG lipase), monoacyl glycerol lipase (MAGL), fatty acid amino hydrolase (FAAH)). At the same time, the antioxidant potential of CBD is due not only to the molecular structure but also to the fact that this compound increases the expression of the main endogenous antioxidant systems, superoxide dismutase (SOD), and glutathione peroxidase (GPx), through the nuclear complex erythroid 2-related factor (Nrf2)/Keep1. Regarding the role in the control of inflammation, this function is exercised by inhibiting (nuclear factor kappa B) NF-κB, and also the genes that encode the expression of molecules with a pro-inflammatory role (cytokines and metalloproteinases). The other effects of CBD on cognitive function and physical performance should not be excluded. In conclusion, the CBD market needs to be regulated more thoroughly, given the previously listed properties, with the mention that the safety profile is a very good one.