Meshfree implementation of individualized active cardiac dynamics

• Published in: Computerized medical imaging and graphics Vol. 34; no. 1; pp. 91 - 103
• Main Authors: Wong, Ken C.L., Wang, Linwei, Zhang, Heye, Liu, Huafeng, Shi, Pengcheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.01.2010
• Subjects: Animals; Cardiac image analysis; Cardiac physiome model; Computational cardiology; Computer Simulation; Finite element methods; Heart Conduction System - anatomy & histology; Heart Conduction System - physiology; Humans; Internal Medicine; Medical image analysis; Meshfree methods; Meshless methods; Models, Anatomic; Models, Cardiovascular; Myocardial Contraction - physiology; Other; Meshfree methods; Meshless methods; Medical image analysis; Cardiac image analysis; Finite element methods; Cardiac physiome model; Computational cardiology
• ISSN: 0895-6111; 1879-0771; 1879-0771
• DOI: 10.1016/j.compmedimag.2009.05.002

The cardiac physiome model has been proven to be useful for cardiac simulation, and has been more recently utilized to medical image analysis. To perform individualized analysis, structural images are necessary to provide subject-specific cardiac geometries. Although finite element methods have been extensively used for the spatial discretization of the myocardium, their complicated meshing procedures and element-based interpolation functions often result in algorithms which are either easy to implement but numerically inaccurate, or accurate but labor-intensive. In consequence, we have adopted the meshfree platform which provides element-free approximations for computational cardiology. Complicated volume meshing procedures are excluded, and no re-meshing is needed for improving spatial accuracy when deformation occurs. Furthermore, the polynomial bases for spatial approximation are not limited by the element structure. As a result, the meshfree platform is more adaptive to different cardiac geometries and thus beneficial to individualized analysis. In this paper, the cardiac physiome model tailored for medical image analysis is presented with its detailed 3D implementation using the meshfree methods. Experiments were performed to compare the meshfree methods with the finite element methods, and simulations were done on a cubical object to investigate the local behaviors of the cardiac physiome model, and on a human heart geometry extracted from a magnetic resonance image to verify its physiological plausibility.