Parenthood in adult female survivors treated for Hodgkin's lymphoma during childhood and adolescence: a prospective, longitudinal study

• Published in: The lancet oncology Vol. 16; no. 6; pp. 667 - 675
• Main Authors: Brämswig, Jürgen H, Prof, Riepenhausen, Marianne, PhD, Schellong, Günther, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2015; Elsevier Limited
• Subjects: Adolescent; Adult; Child; Combined Modality Therapy; Cyclophosphamide - administration & dosage; Entrepreneurs; Female; Follow-Up Studies; Hematology, Oncology and Palliative Medicine; Hodgkin Disease - drug therapy; Hodgkin Disease - epidemiology; Hodgkin Disease - pathology; Humans; Infertility; Lymphoma; Medical research; Middle Aged; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Parenting; Procarbazine - administration & dosage; Prognosis; Studies; Survivors
• ISSN: 1470-2045; 1474-5488
• DOI: 10.1016/S1470-2045(15)70140-3

Summary Background Little is known about parenthood in women who were treated for Hodgkin's lymphoma during childhood and adolescence. We aimed to assess the frequency of parenthood in female survivors of Hodgkin's lymphoma younger than 18 years at diagnosis, and to compare it with that in a female population control group. Methods In this prospective, longitudinal study, our cohort consisted of 590 female patients younger than 18 years at diagnosis who participated in one of five Hodgkin's lymphoma treatment studies between June 19, 1978, and July 12, 1995. Women who had been followed up for 5 years or longer, were in continuous complete remission, and had no second malignancy or Hodgkin's lymphoma relapse before parenthood were included in our parenthood analysis. Parenthood was defined as the delivery of a liveborn child. Frequency of parenthood was compared with that in the German female population aged 16–49 years, using data from the 2012 Mikrozensus population survey. We assessed parenthood by estimating cumulative incidences and hazard ratios (HRs) with associated variables. Findings 467 of 590 patients in our cohort had long-term follow-up (median 20·4 years [IQR 16·3–24·8]) and were in continuous complete remission. 228 (49%) of 467 patients had 406 children (median of 1·78 children per mother, range 1–7). Cumulative incidences of parenthood were 67% (95% CI 64–75) at 27·7 years of follow-up (the longest number of years that a patient was followed up before she had her first child) and 69% (61–74) at 39·8 years of age (the oldest age of a patient before she had her first child). The incidence of parenthood did not differ between our cohort and the female German population for any age group up to 49 years, except for the 66 women aged 40–44 years at the time of last information, who had a significantly lower frequency of parenthood compared with the general population (40 [61%] of 66 vs 2 208 000 [78%] of 2 847 000; p=0·001). Procarbazine in cumulative doses up to 11 400 mg/m2 , cyclophosphamide in cumulative doses up to 6000 mg/m2 , alkylating agent dose scores of 1–5, therapy group based on disease stage at diagnosis, abdominal and supradiaphragmatic radiation, and age at treatment had no significant or only minor effects on parenthood. Parenthood was significantly reduced in survivors receiving pelvic radiation compared with those who received abdominal and supradiaphragmatic radiation (HR 0·76, 95% CI 0·61–0·95; p=0·01). Interpretation The results of this study document an overall favourable prognosis for parenthood in female survivors of Hodgkin's lymphoma. They will assist counselling of female survivors about their positive potential for future parenthood. Funding Deutsche Kinderkrebsstiftung, Jens-Brunken-Stiftung für Leukämie und Lymphomforschung, and Kinderkrebshilfe Münster.