Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives

Cyanoacrylate glues are easily applied to wounds with good cosmetic results. However, they tend to be brittle and can induce local tissue toxicity. A series of cyanoacrylate monomers with a flexible ether linkage and varying side-chain lengths was synthesized and characterized for potential use as t...

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Bibliographic Details
Published inActa biomaterialia Vol. 7; no. 8; pp. 3150 - 3157
Main Authors Mizrahi, Boaz, Stefanescu, Cristina F., Yang, Celine, Lawlor, Michael W., Ko, Dennis, Langer, Robert, Kohane, Daniel S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2011
Subjects
Adhesiveness
adhesives
Animals
Biocompatibility
Biomedical materials
Cell Death
Cell Survival
Cyanoacrylates
Cyanoacrylates - adverse effects
Cyanoacrylates - chemical synthesis
Cyanoacrylates - chemistry
cytotoxicity
Elasticity
formaldehyde
Formaldehyde - analysis
HeLa Cells
Humans
In vitro testing
In vivo tests
Magnetic Resonance Spectroscopy
Male
Materials Testing
Mechanical properties
Monomers
oxygen
Polymerization
Rats
Rats, Sprague-Dawley
Surgical glue
Surgical implants
Tissue adhesives
Tissue Adhesives - adverse effects
Tissue Adhesives - chemical synthesis
Tissue Adhesives - chemistry
Toxicity
Mechanical properties
Cyanoacrylates
Surgical glue
Biocompatibility
Tissue adhesives
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Summary:Cyanoacrylate glues are easily applied to wounds with good cosmetic results. However, they tend to be brittle and can induce local tissue toxicity. A series of cyanoacrylate monomers with a flexible ether linkage and varying side-chain lengths was synthesized and characterized for potential use as tissue adhesives. The effect of side-chain length on synthesis yield, physical and mechanical properties, formaldehyde generation, cytotoxicity in vitro and biocompatibility in vivo were examined. The incorporation of etheric oxygen allowed the production of flexible monomers with good adhesive strength. Monomers with longer side-chains were found to have less toxicity both in vitro and in vivo. Polymerized hexoxyethyl cyanoacrylate was more elastic than its commercially available and widely used alkyl analog 2-octyl cyanoacrylate, without compromising biocompatibility.
Bibliography:http://dx.doi.org/10.1016/j.actbio.2011.04.022
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2011.04.022