Identification of a variant antigenic neutralizing epitope in hypervariable region 1 of avian leukosis virus subgroup J

• Published in: Vaccine Vol. 34; no. 11; pp. 1399 - 1404
• Main Authors: Hou, Minbo, Zhou, Defang, Li, Gen, Guo, Huijun, Liu, Jianzhu, Wang, Guihua, Zheng, Qiankun, Cheng, Ziqiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 08.03.2016; Elsevier Limited
• Subjects: Allergy and Immunology; Amino Acid Sequence; Animals; Antibodies, Monoclonal - immunology; Antibodies, Viral - blood; Antigenic Variation; Antigens; Antigens, Viral - genetics; Antigens, Viral - immunology; Avian leukosis virus; Avian Leukosis Virus - genetics; Avian Leukosis Virus - immunology; Avian leukosis virus subgroup J; Bioinformatics; Chickens; Conflicts of interest; Epitopes, B-Lymphocyte - genetics; Experiments; Genes; Immunization; Laboratories; Neutralization Tests; Poultry; Proteins; Retroviridae; Reverse vaccinology; Vaccines; Variant epitope; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Viruses; China; Reverse vaccinology; Avian leukosis virus subgroup J; Variant epitope
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.01.039

Highlights • Antibody induced by predicted B-cell multi-epitope protein can neutralize and recognize three different strains of ALV-J. • A variant antigenic neutralizing epitope was identified using reverse vaccinology methods. • The founder epitope and its variants can react with all anti-ALV-J sera from field, indicating the potential value for the novel multi-epitope vaccine development.