CT severity score: an imaging biomarker to estimate the severity of COVID-19 pneumonia in vaccinated and non-vaccinated population
Background In India, two vaccines received emergent use authorization, namely Covishield (a brand of the Oxford—Astra Zeneca vaccine manufactured by the Serum institute of India) and Covaxin (developed by Bharat Biotech) against COVID-19 disease. Chest CT is an objective way to assess the extent of...
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Published in | Egyptian Journal of Radiology and Nuclear Medicine Vol. 53; no. 1; pp. 1 - 8 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
12.04.2022
Springer Springer Nature B.V SpringerOpen |
Subjects | |
Online Access | Get full text |
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Summary: | Background
In India, two vaccines received emergent use authorization, namely Covishield (a brand of the Oxford—Astra Zeneca vaccine manufactured by the Serum institute of India) and Covaxin (developed by Bharat Biotech) against COVID-19 disease. Chest CT is an objective way to assess the extent of pulmonary parenchymal involvement. This study aims to estimate the disease severity and outcome due to COVID-19 among vaccinated and non-vaccinated symptomatic patients and compare the same in Covishield versus Covaxin recipients using CT severity score.
Results
A total of 306 patients were retrospectively evaluated. The mean age was 62.56 ± 8.9 years, and males [
n
-208 (67.97%)] were commonly affected. Of 306 patients, 143 were non-vaccinated (47%), 124 were partially vaccinated (40%), and 39 were completely vaccinated (13%). CT severity scores were reduced in both Covishield and Covaxin recipients in comparison with the non-vaccinated group [
χ
2
(2) = 16.32,
p
< 0.001]. There is a reduction in LOS among the vaccinated group, predominantly among the Covishield recipients.
Conclusion
Vaccination confers protection from severe SARS-CoV2 infection and is associated with an overall reduction in mortality. |
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ISSN: | 0378-603X 2090-4762 |
DOI: | 10.1186/s43055-022-00768-2 |