Hypotony in Patients with Uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

• Published in: Ocular immunology and inflammation Vol. 20; no. 2; pp. 104 - 112
• Main Authors: Sen, H. Nida, Drye, Lea T., Goldstein, Debra A., Larson, Theresa A., Merrill, Pauline T., Pavan, Peter R., Sheppard, John D., Burke, Alyce, Srivastava, Sunil K., Jabs, Douglas A.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.04.2012; Taylor & Francis
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Adult; African Continental Ancestry Group - statistics & numerical data; Animals; European Continental Ancestry Group - statistics & numerical data; Female; Humans; hypotony; Male; Middle Aged; multicenter uveitis steroid treatment trial; Ocular Hypotension - drug therapy; Ocular Hypotension - epidemiology; Ocular Hypotension - ethnology; Ocular Hypotension - etiology; Prevalence; Severity of Illness Index; Treatment Outcome; uveitis; Uveitis - complications; Uveitis - drug therapy; Uveitis - epidemiology; Uveitis - ethnology; Visual Acuity - drug effects; visual impairment; visual loss; Young Adult
• ISSN: 0927-3948; 1744-5078; 1744-5078
• DOI: 10.3109/09273948.2011.647228

Purpose: To assess the prevalence of hypotony in patients with severe forms of uveitis. Methods: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified. Results: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01). Conclusions: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.