Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine

• Published in: Vaccine Vol. 30; no. 16; pp. 2647 - 2653
• Main Authors: Tomovici, A, Barreto, L, Zickler, P, Meekison, W, Noya, F, Voloshen, T, Lavigne, P
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 30.03.2012; Elsevier Limited
• Subjects: Adolescence; Adolescent; Adolescents; Adult; adults; Age; Age Factors; Allergy and Immunology; Antibodies; Antibodies, Bacterial - blood; Antibodies, Bacterial - immunology; antigens; Antitoxins; Child; Clinical trials; Combined vaccines; Confidence intervals; Data processing; Diphtheria; Diphtheria - immunology; Diphtheria - microbiology; Diphtheria - prevention & control; Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology; Female; Follow-Up Studies; Humans; humoral immunity; Immune response (humoral); Immunity, Active; Immunity, Humoral; Immunization; Immunization, Secondary; Male; Middle Aged; Morbidity; Pertussis; secondary immunization; Serology; seroprevalence; Statistical analysis; Studies; Teenagers; Tetanus; Tetanus - immunology; Tetanus - microbiology; Tetanus - prevention & control; Toxoids; Vaccine; Vaccines; Vaccines, Combined; Whooping Cough - immunology; Whooping Cough - microbiology; Whooping Cough - prevention & control; Canada; Pertussis; Vaccine; Serology
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.02.013

Highlights ► We examined protective responses 1, 3, 5, and 10 years after Tdap vaccination. ► In 99% of adolescents, anti-diphtheria and anti-tetanus antibodies lasted 10 years. ► Seropositivity to ≥1 pertussis antigen persisted in most adolescents for 10 years. ► Adults responded to Tdap similarly to adolescents. ► Ten years is a reasonable interval for a Tdap vaccine booster dose.