Theory for nanoparticle retention time in the helical channel of quadrupole magnetic field-flow fractionation

Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and...

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Published inJournal of magnetism and magnetic materials Vol. 321; no. 10; pp. 1446 - 1451
Main Authors Williams, P. Stephen, Carpino, Francesca, Zborowski, Maciej
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.2009
Elsevier
Subjects
Applied sciences
Chemical engineering
Exact sciences and technology
Field-flow fractionation
Helical channel
Liquid-liquid and fluid-solid mechanical separations
Magnetic field-flow fractionation
Magnetic nanoparticles
MgFFF
Miscellaneous
Nanoparticle characterization
Quadrupole magnetic field
MgFFF
Magnetic field-flow fractionation
Nanoparticle characterization
Magnetic nanoparticles
Field-flow fractionation
Helical channel
Quadrupole magnetic field
Field flow fractionation
Magnetic particles
Nanoparticle
Velocity distribution
Quadrupole field
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Abstract Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and sample components therefore have angular and longitudinal components to their motion in the thin annular space occupied by the helical channel. The retention ratio is defined as the ratio of the times for non-retained and a retained material to pass through the channel. Equations are derived for the respective angular and longitudinal components to retention ratio.
AbstractList Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and sample components therefore have angular and longitudinal components to their motion in the thin annular space occupied by the helical channel. The retention ratio is defined as the ratio of the times for non retained and a retained material to pass through the channel. Equations are derived for the respective angular and longitudinal components to retention ratio.
Author Williams, P. Stephen
Zborowski, Maciej
Carpino, Francesca
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crossref_primary_10_1098_rsta_2010_0133
crossref_primary_10_1016_j_aca_2011_02_019
crossref_primary_10_1021_cr9001929
Cites_doi 10.1081/SS-120014809
10.1021/ac030152n
10.1021/ac020649h
10.1021/j100261a048
10.1021/ac00292a039
10.1021/j150606a025
10.1126/science.8502990
10.1002/bit.21202
10.1080/01496398408060668
10.1016/j.jmmm.2006.11.162
10.1088/1742-6596/17/1/024
10.1016/j.jmmm.2005.01.071
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Issue 10
Keywords MgFFF
Magnetic field-flow fractionation
Nanoparticle characterization
Magnetic nanoparticles
Field-flow fractionation
Helical channel
Quadrupole magnetic field
Field flow fractionation
Magnetic particles
Nanoparticle
Velocity distribution
Quadrupole field
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Contact Author: P. Stephen Williams, Department of Biomedical Engineering/ND-20, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Fax: (216) 444-9198. Tel.: (216) 444-1217. E-mail: willias3@ccf.org
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SubjectTerms Applied sciences
Chemical engineering
Exact sciences and technology
Field-flow fractionation
Helical channel
Liquid-liquid and fluid-solid mechanical separations
Magnetic field-flow fractionation
Magnetic nanoparticles
MgFFF
Miscellaneous
Nanoparticle characterization
Quadrupole magnetic field
Title Theory for nanoparticle retention time in the helical channel of quadrupole magnetic field-flow fractionation
URI https://dx.doi.org/10.1016/j.jmmm.2009.02.065
https://www.ncbi.nlm.nih.gov/pubmed/20161002
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