Theory for nanoparticle retention time in the helical channel of quadrupole magnetic field-flow fractionation

• Published in: Journal of magnetism and magnetic materials Vol. 321; no. 10; pp. 1446 - 1451
• Main Authors: Williams, P. Stephen, Carpino, Francesca, Zborowski, Maciej
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2009; Elsevier
• Subjects: Applied sciences; Chemical engineering; Exact sciences and technology; Field-flow fractionation; Helical channel; Liquid-liquid and fluid-solid mechanical separations; Magnetic field-flow fractionation; Magnetic nanoparticles; MgFFF; Miscellaneous; Nanoparticle characterization; Quadrupole magnetic field; MgFFF; Magnetic field-flow fractionation; Nanoparticle characterization; Magnetic nanoparticles; Field-flow fractionation; Helical channel; Quadrupole magnetic field; Field flow fractionation; Magnetic particles; Nanoparticle; Velocity distribution; Quadrupole field
• ISSN: 0304-8853
• DOI: 10.1016/j.jmmm.2009.02.065

Quadrupole magnetic field-flow fractionation (QMgFFF) is a separation and characterization technique for magnetic nanoparticles such as those used for cell labeling and for targeted drug therapy. A helical separation channel is used to efficiently exploit the quadrupole magnetic field. The fluid and sample components therefore have angular and longitudinal components to their motion in the thin annular space occupied by the helical channel. The retention ratio is defined as the ratio of the times for non-retained and a retained material to pass through the channel. Equations are derived for the respective angular and longitudinal components to retention ratio.