New Amino-Acid Conjugates of Glycyrrhizic Acid

• Published in: Chemistry of natural compounds Vol. 50; no. 2; pp. 317 - 320
• Main Authors: Baltina, L. A., Jr, Stolyarova, O. V, Baltina, L. A, Kondratenko, R. M, Fedorova, V. A, Orshanskaya, Ya. A, Zarubaev, V. V
• Format: Journal Article
• Language: English
• Published: Boston Springer-Verlag 01.05.2014; Springer US; Springer Nature; Springer; Springer Nature B.V
• Subjects: 6-aminohexanoic acid; Acids; Amino acids; Antiviral agents; antiviral properties; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Conjugates; Esters; glycyrrhizin; Health aspects; Influenza A virus; Life Sciences & Biomedicine; Medicine; Organic Chemistry; Pharmacology & Pharmacy; Pharmacy; Physical Sciences; Plant Sciences; Science & Technology; Viruses; conjugates; antiviral activity; glycyrrhizic acid; amino acids; influenza A virus (H1N1)
• ISSN: 0009-3130; 1573-8388
• DOI: 10.1007/s10600-014-0941-9

New conjugates of glycyrrhizic acid (GA) containing two amino-acid methyl esters (4-aminobutanoic, 6-aminohexanoic, 11-aminoundecanoic) were synthesized by the activated-ester method using N-hydroxysuccinimide (HOSu)-N,N′-dicyclohexylcarbodiimide (DCC). The conjugate of GA with 6-aminohexanoic acid possessed pronounced antiviral activity against influenza virus AH1N1/pdm09 with EC₅₀ = 12.7 μM and SI = 32.