Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

• Published in: New England Journal of Medicine Vol. 385; no. 9; pp. 790 - 802
• Main Authors: Goligher, Ewan C, Berger, Jeffrey S, Neal, Matthew D, Rosenson, Robert S, Reynolds, Harmony R, Turgeon, Alexis F, Huang, David T, Bradbury, Charlotte A, Kornblith, Lucy Z, Kumar, Anand, Kahn, Susan R, Cushman, Mary, Gordon, Anthony C, Kirwan, Bridget-Anne, Higgins, Alisa M, Lewis, Roger J, Lorenzi, Elizabeth, Berry, Scott M, Berry, Lindsay R, Annane, Djillali, Arabi, Yaseen M, Baumann Kreuziger, Lisa, Billett, Henny H, Bond, Lindsay, Brunkhorst, Frank, Buzgau, Adrian, Castellucci, Lana A, Chekuri, Sweta, Chen, Jen-Ting, Chkhikvadze, Tamta, Coiffard, Benjamin, Costantini, Todd W, Detry, Michelle A, Duggal, Abhijit, Džavík, Vladimír, Estcourt, Lise J, Fitzgerald, Mark, Fowler, Robert A, Galanaud, Jean P, Gandotra, Sheetal, García-Madrona, Sebastian, Godoy, Lucas C, Goodman, Andrew L, Green, Cameron, Greenstein, Yonatan Y, Gross, Peter L, Haniffa, Rashan, Hanna, Nicholas, Hegde, Sheila M, Hendrickson, Carolyn M, Hite, R Duncan, Hindenburg, Alexander A, Hope, Aluko A, Horowitz, James M, Hudock, Kristin, Hunt, Beverley J, Iyer, Vivek N, Jacobson, Jeffrey R, Keller, Norma M, King, Andrew J, Knudson, M Margaret, Krishnan, Vidya, Laffan, Michael A, Lamontagne, Francois, Leifer, Eric S, Linstrum, Kelsey, Litton, Edward, Lopez-Sendon Moreno, Jose L, Malhotra, Saurabh, Marcos, Miguel, Matthay, Michael A, McAuley, Daniel F, McDonald, Emily G, Moore, Steven C, Morillo Guerrero, Raquel, Mouncey, Paul R, Nair, Girish B, Pandey, Ambarish, Paul, Jonathan D, Pérez González, Yessica S, Pompilio, Mauricio, Quigley, John G, Santos, Fernanda O, Santos, Marlene, Olombrada Santos, Mayler, Schutgens, Roger E G, Seymour, Christopher W, Silva, Jr, Delcio G, Sheehan, John P, Singhal, Aneesh B, Stanworth, Simon J, Tritschler, Tobias, Turner, Anne M, van de Veerdonk, Frank L, Wahid, Lana, Wells, Bryan J, Widmer, R Jay, Zampieri, Fernando G, Webb, Steven A, Zarychanski, Ryan
• Format: Journal Article Web Resource
• Language: English
• Published: United States Massachusetts Medical Society 26.08.2021
• Subjects: Adult; Aged; Anticoagulants; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Anticoagulation; Bayesian analysis; Cardiology; Coronavirus; Coronaviruses; COVID-19; COVID-19 - mortality; COVID-19 Drug Treatment; Critical Care; Embolisms; Enrollments; Female; Hemorrhage - chemically induced; Heparin; Heparin - administration & dosage; Heparin - adverse effects; Heparin - therapeutic use; Heparin, Low-Molecular-Weight - therapeutic use; Hospital Mortality; Hospitalization; Humans; Infectious Disease; Laboratories; Life Sciences; Male; Mathematical models; Middle Aged; Original; Patients; Pulmonary; Respiratory organs; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Survival; Survival Analysis; Thromboembolism; Thrombosis; Thrombosis - prevention & control; Ventilators
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2105911

In a randomized trial, patients with moderately severe Covid-19 were assigned to receive either therapeutic-dose anticoagulation or usual-care thromboprophylaxis. At 21 days, therapeutic-dose anticoagulation resulted in a higher probability of survival until hospital discharge without organ support.