Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study

• Published in: Metabolites Vol. 13; no. 2; p. 250
• Main Authors: Fuke, Nobuo, Yamashita, Takahiro, Shimizu, Sunao, Matsumoto, Mai, Sawada, Kaori, Jung, Songee, Tokuda, Itoyo, Misawa, Mina, Suzuki, Shigenori, Ushida, Yusuke, Mikami, Tatsuya, Itoh, Ken, Suganuma, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Alzheimer's disease; Bacteria; Binding proteins; Body composition; Creatinine; Cross-sectional studies; cross-sectional study; Diabetes; diet; Digestive system; Ethics; Food and nutrition; Food habits; Food intake; Gastrointestinal tract; gut microbiota; Habits; Health promotion; health status; Health surveys; Inflammation; Insulin resistance; Intestinal microflora; Intestine; Japanese; Lipopolysaccharide-binding protein; Lipopolysaccharides; LPS-binding protein; Medical research; Medicine, Experimental; metabolic endotoxemia; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Nutrients; Overweight; Physiological aspects; Plasma; Population studies; Proteins; Renin; Thyroxine; Womens health; Japan; health status; lipopolysaccharide-binding protein; cross-sectional study; diet; gut microbiota; metabolic endotoxemia
• ISSN: 2218-1989; 2218-1989
• DOI: 10.3390/metabo13020250

The influx of intestinal bacteria-derived lipopolysaccharide (LPS) into the blood has attracted attention as a cause of diseases. The aim of this study is investigating the associations between the influx of LPS, dietary factors, gut microbiota, and health status in the general adult population. Food/nutrient intake, gut microbiota, health status and plasma LPS-binding protein (LBP; LPS exposure indicator) were measured in 896 residents (58.1% female, mean age 54.7 years) of the rural Iwaki district of Japan, and each correlation was analyzed. As the results, plasma LBP concentration correlated with physical (right/left arms' muscle mass [ = -0.02, -0.03]), renal (plasma renin activity [ = 0.27], urine albumin creatinine ratio [ = 0.50]), adrenal cortical (cortisol [ = 0.14]), and thyroid function (free thyroxine [ = 0.05]), iron metabolism (serum iron [ = -0.14]), and markers of lifestyle-related diseases (all s < 0.20). Plasma LBP concentration were mainly negatively correlated with vegetables/their nutrients intake (all ≤ -0.004, s < 0.20). Plasma LBP concentration was positively correlated with the proportion of ( = 0.32), ( = 0.56), and ( = 0.65); and negatively correlated with ( = -0.57) (all s < 0.20). Dietary factors correlated with plasma LBP concentration correlated with positively (all s ≥ 0.07) or negatively (all s ≤ -0.07) the proportion of these bacteria (all s < 0.20). Our results suggested that plasma LBP concentration in the Japanese general adult population was associated with various health issues, and that dietary habit was associated with plasma LBP concentration in relation to the intestinal bacteria.