PEG hydrogel degradation and the role of the surrounding tissue environment
Poly(ethylene glycol) (PEG)‐based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue‐like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these st...
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Published in | Journal of tissue engineering and regenerative medicine Vol. 9; no. 3; pp. 315 - 318 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.03.2015
Hindawi Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Poly(ethylene glycol) (PEG)‐based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue‐like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses. Copyright © 2013 John Wiley & Sons, Ltd. |
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Bibliography: | ark:/67375/WNG-JHS9L6C5-H NIH/NIDCR - No. 3R01DE016887-03S1 istex:28ECAA95E74E85FD3E40A9B7816F23C16A52FD4C ArticleID:TERM1688 |
ISSN: | 1932-6254 1932-7005 |
DOI: | 10.1002/term.1688 |