Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a High-Fat Diet

• Published in: Journal of food science Vol. 76; no. 1; pp. H7 - H10
• Main Authors: Son, Myoung Jin, Rico, Catherine W., Nam, Seok Hyun, Kang, Mi Young
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.01.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Acids; Animals; Antioxidants - therapeutic use; Biological and medical sciences; Blood Glucose - analysis; Coumaric Acids - therapeutic use; diabetes; Diet; Dietary Fats - adverse effects; Feeding. Feeding behavior; ferulic acid; Food industries; Food science; Fundamental and applied biological sciences. Psychology; Glucokinase - metabolism; Glucose; Glucose - metabolism; Glucose-6-Phosphatase - metabolism; Glycogen - metabolism; high-fat-fed mice; Hyperglycemia - blood; Hyperglycemia - metabolism; Hyperglycemia - prevention & control; Hypoglycemic Agents - therapeutic use; hypoglycemic effect; Insulin - blood; Liver - drug effects; Liver - enzymology; Liver - metabolism; Male; Metabolism; Mice; Mice, Inbred C57BL; Oils & fats; oryzanol; Phenylpropionates - therapeutic use; Phosphoenolpyruvate Carboxykinase (GTP) - metabolism; Random Allocation; Rodents; Time Factors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Phenolic acid; oryzanol; Rodentia; Glucose; Metabolism; Ferulic acid; Vertebrata; Mammalia; Diet; Mouse; Fat; hypoglycemic effect; Carbohydrate; diabetes; high-fat-fed mice
• ISSN: 0022-1147; 1750-3841
• DOI: 10.1111/j.1750-3841.2010.01907.x

:  The effects of oryzanol and ferulic acid on the glucose metabolism of high‐fat‐fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high‐fat (17%) diet; HF‐O group fed with high‐fat diet supplemented with 0.5% oryzanol; and HF‐FA group fed with high‐fat diet supplemented with 0.5% ferulic acid. All animals were allowed free access to the experimental diets and water for 7 wk. At the end of the experimental period, the HF‐O and HF‐FA groups exhibited significantly lower blood glucose level and glucose‐6‐phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities, and higher glycogen and insulin concentrations and glucokinase (GK) activity compared with NC and HF groups. The results of this study illustrate that both oryzanol and ferulic acid could reduce the risk of high‐fat diet‐induced hyperglycemia via regulation of insulin secretion and hepatic glucose‐regulating enzyme activities.