Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a High-Fat Diet
: The effects of oryzanol and ferulic acid on the glucose metabolism of high‐fat‐fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high‐fat (17%) diet; HF‐O group fed with high‐fat diet supplemented with 0.5%...
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Published in | Journal of food science Vol. 76; no. 1; pp. H7 - H10 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.01.2011
Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | : The effects of oryzanol and ferulic acid on the glucose metabolism of high‐fat‐fed mice were investigated. Male C57BL/6N mice were randomly divided into 4 groups: NC group fed with normal control diet; HF group fed with high‐fat (17%) diet; HF‐O group fed with high‐fat diet supplemented with 0.5% oryzanol; and HF‐FA group fed with high‐fat diet supplemented with 0.5% ferulic acid. All animals were allowed free access to the experimental diets and water for 7 wk. At the end of the experimental period, the HF‐O and HF‐FA groups exhibited significantly lower blood glucose level and glucose‐6‐phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) activities, and higher glycogen and insulin concentrations and glucokinase (GK) activity compared with NC and HF groups. The results of this study illustrate that both oryzanol and ferulic acid could reduce the risk of high‐fat diet‐induced hyperglycemia via regulation of insulin secretion and hepatic glucose‐regulating enzyme activities. |
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Bibliography: | ArticleID:JFDS1907 istex:0486BA7E681CC8CDA5C41146280748B610B6D162 ark:/67375/WNG-X28F9TJ9-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-1147 1750-3841 |
DOI: | 10.1111/j.1750-3841.2010.01907.x |