One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons

Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of...

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Published inThe EMBO journal Vol. 35; no. 18; pp. 1957 - 1959
Main Author Castro, Diogo S
Format Journal Article
LanguageEnglish
Published London Blackwell Publishing Ltd 15.09.2016
Nature Publishing Group UK
Springer Nature B.V
John Wiley and Sons Inc
Subjects
Dopamine
EMBO11
EMBO27
Neurons
News & Views
Oxidative stress
Parkinson's disease
Transcription factors
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Abstract Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design. Graphical Abstract The homeobox transcription factor Pbx1 regulates dopaminergic neuronal development and protects them from oxidative stress.
AbstractList Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design.
Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal, Villaescusa et al () show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design. The homeobox transcription factor Pbx1 regulates dopaminergic neuronal development and protects them from oxidative stress.
Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal, Villaescusa et al show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design.
Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design. Graphical Abstract The homeobox transcription factor Pbx1 regulates dopaminergic neuronal development and protects them from oxidative stress.
Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( ) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design.
Author Castro, Diogo S
AuthorAffiliation 1 Molecular Neurobiology Laboratory Instituto Gulbenkian de Ciência Oeiras Portugal
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10.1073/pnas.0506580102
10.15252/embj.201593725
10.1126/science.276.5310.248
10.1186/1749-8104-7-24
10.1242/dev.097394
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10.1002/dvdy.24075
10.1007/s00204-012-0919-y
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  publication-title: Arch Toxicol
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  start-page: 1963
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Snippet Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue...
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StartPage 1957
SubjectTerms Dopamine
EMBO11
EMBO27
Neurons
News & Views
Oxidative stress
Parkinson's disease
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Title One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons
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https://link.springer.com/article/10.15252/embj.201695353
https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fembj.201695353
https://www.ncbi.nlm.nih.gov/pubmed/27534772
https://www.proquest.com/docview/1880131750
https://www.proquest.com/docview/1820601114
https://pubmed.ncbi.nlm.nih.gov/PMC5282835
Volume 35
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