One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons

Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of...

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Bibliographic Details
Published inThe EMBO journal Vol. 35; no. 18; pp. 1957 - 1959
Main Author Castro, Diogo S
Format Journal Article
LanguageEnglish
Published London Blackwell Publishing Ltd 15.09.2016
Nature Publishing Group UK
Springer Nature B.V
John Wiley and Sons Inc
Subjects
Dopamine
EMBO11
EMBO27
Neurons
News & Views
Oxidative stress
Parkinson's disease
Transcription factors
Views
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Summary:Midbrain dopaminergic neurons have been the subject of intense research, because of their importance in pathologies such as Parkinson's disease. In this issue of The EMBO Journal , Villaescusa et al ( 2016 ) show the transcription factor Pbx1 is required for the differentiation and survival of midbrain dopaminergic neurons. Notably, Pbx1 protects from oxidative stress by inducing Nfe2l1, and the expression of both genes is reduced in dopaminergic neurons from Parkinson's patients. This is an important study, with possible implications in regenerative medicine and drug design. Graphical Abstract The homeobox transcription factor Pbx1 regulates dopaminergic neuronal development and protects them from oxidative stress.
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ArticleID:EMBJ201695353
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ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201695353