A Multifunctional Nanomicelle for Real-Time Targeted Imaging and Precise Near-Infrared Cancer Therapy
Simultaneous targeted cancer imaging, therapy and real‐time therapeutic monitoring can prevent over‐ or undertreatment. This work describes the design of a multifunctional nanomicelle for recognition and precise near‐infrared (NIR) cancer therapy. The nanomicelle encapsulates a new pH‐activatable fl...
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Published in | Angewandte Chemie (International ed.) Vol. 53; no. 36; pp. 9544 - 9549 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.09.2014
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | Simultaneous targeted cancer imaging, therapy and real‐time therapeutic monitoring can prevent over‐ or undertreatment. This work describes the design of a multifunctional nanomicelle for recognition and precise near‐infrared (NIR) cancer therapy. The nanomicelle encapsulates a new pH‐activatable fluorescent probe and a robust NIR photosensitizer, R16FP, and is functionalized with a newly screened cancer‐specific aptamer for targeting viable cancer cells. The fluorescent probe can light up the lysosomes for real‐time imaging. Upon NIR irradiation, R16FP‐mediated generation of reactive oxygen species causes lysosomal destruction and subsequently trigger lysosomal cell death. Meanwhile the fluorescent probe can reflect the cellular status and in situ visualize the treatment process. This protocol can provide molecular information for precise therapy and therapeutic monitoring.
All in one: A lysosome‐aimed multifunctional nanomicelle (Apt‐TNP) was developed by integrating a target‐cell‐specific aptamer, a pH‐activatable fluorescent probe, and a near‐infrared photosensitizer. Apt‐TNP enables simultaneous cancer imaging, photodynamic therapy, and real‐time self‐feedback of therapeutic efficacy. |
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Bibliography: | istex:0FABFEBFC388138DB5FB42851C589FABB87FAC7E ark:/67375/WNG-14CKSRDN-S ArticleID:ANIE201405490 National Science Fund for Creative Research Groups - No. 21121091; No. 21021062 This study was supported by the National Basic Research Program (2010CB732400), the National Science Fund for Creative Research Groups (21121091 and 21021062) and the National Natural Science Foundation of China (21322506, 21005037, 21135002, 91213301, 20875045). National Basic Research Program - No. 2010CB732400 National Natural Science Foundation of China - No. 21322506; No. 21005037; No. 21135002; No. 91213301; No. 20875045 These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201405490 |