Branching and converging pathways in fungal natural product biosynthesis

In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end product...

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Bibliographic Details
Published inFungal biology and biotechnology Vol. 9; no. 1; p. 6
Main Authors Wei, Xingxing, Wang, Wei-Guang, Matsuda, Yudai
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 07.03.2022
BioMed Central
BMC
Subjects
Amino acids
Biosynthesis
Branching and converging pathways
Fatty acids
Natural products
Product introduction
Review
Natural products
Branching and converging pathways
Biosynthesis
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Summary:In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end products. A natural product can also be synthesized by the fusion of two or more precursors generated from separate metabolic pathways. This review article summarizes several representative branching and converging pathways in fungal natural product biosynthesis to illuminate how fungi are capable of synthesizing a diverse array of natural products.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2054-3085
2054-3085
DOI:10.1186/s40694-022-00135-w