Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study

• Published in: Journal of inflammation research Vol. 15; pp. 5945 - 5957
• Main Authors: Li, Jun, He, Di, Yu, Jiazhou, Chen, Shuohua, Wu, Qiong, Cheng, Zongxue, Wei, Qiaohui, Xu, Yuying, Zhu, Yimin, Wu, Shouling
• Format: Journal Article
• Language: English
• Published: Macclesfield Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: 2008; 2010 were assessed by dynamic trajectories (primary exposure); 95% ci=1.01-1.25) while no significant association was found for ‘decrease pattern’. the highest group of annual siri increase and average siri had respective hr of 1.25(95% ci=1.09-1.44) and 1.39(95% ci=1.19-1.63). conclusion: dynamic status of sii and siri was significantly associated with risk of cvd; 95% ci=1.17-1.63) and 12% (hr=1.12; adjusted hrs were 1.24(95% ci=1.02-1.51) for ‘increase pattern’ and 1.11(95% ci=1.00-1.23) for ‘moderate-stable pattern’ while the association was not significant for ‘decrease pattern’. additionally; after controlling confounders and level of sii in 2006; and average value. the outcome was cvd incidence during 8.6 years’ follow-up. multiple cox regression models were used to calculate the adjusted hazard ratios (hrs) and confidence intervals (95%cis). results: four dynamic trajectories of sii and siri were identified as follows: low stable pattern; and decrease pattern. for sii; annual increase; background: two novel systemic inflammation indices; Biomarkers; Blood; Blood platelets; Body mass index; Cancer; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Cohort analysis; compared with ‘low stable pattern’; Diabetes; Drug use; Family medical history; Heart attacks; High density lipoprotein; Hypertension; increase pattern; Inflammation; Lymphocytes; moderate stable pattern; Neutrophils; Oncology, Experimental; Original Research; Questionnaires; Regression analysis; Risk factors; sii and siri are associated with increased risk of cardiovascular diseases (cvd). however; sii and siri are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. this study aims to examine the association between the dynamic status of sii and siri and risk of cvd. methods: this prospective study included a total of 45809 subjects without mi; Statistical analysis; Stroke; stroke and cancer prior to or in 2010 (baseline of this study). the dynamic status of sii and siri during 2006; the highest group of annual sii increase and average sii had respective hr of 1.20(95% ci=1.05-1.37) and 1.32(95% ci=1.13-1.55). the results were consistent for siri. ‘increase pattern’ and ‘moderate stable pattern’ increased the risk of cvd by 38%(hr=1.38; Variables; which highlighted that we should focus on the dynamic change of sii and siri; China
• ISSN: 1178-7031; 1178-7031
• DOI: 10.2147/JIR.S378309

Background: Two novel systemic inflammation indices, SII and SIRI, are associated with increased risk of cardiovascular diseases (CVD). However, SII and SIRI are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. This study aims to examine the association between the dynamic status of SII and SIRI and risk of CVD. Methods: This prospective study included a total of 45,809 subjects without MI, stroke and cancer prior to or in 2010 (baseline of this study). The dynamic status of SII and SIRI during 2006, 2008, and 2010 was assessed by dynamic trajectories (primary exposure), annual increase, and average value. The outcome was CVD incidence during 8.6 years' follow-up. Multiple Cox regression models were used to calculate the adjusted hazard ratios (HRs) and confidence intervals (95% CIs). Results: Four dynamic trajectories of SII and SIRI were identified as follows: low stable pattern, moderate stable pattern, increase pattern, and decrease pattern. For SII, compared with "low stable pattern", after controlling confounders and level of SII in 2006, adjusted HRs were 1.24 (95% CI = 1.02-1.51) for "increase pattern" and 1.11 (95% CI = 1.00-1.23) for "moderate-stable pattern" while the association was not significant for "decrease pattern". Additionally, the highest group of annual SII increase and average SII had respective HR of 1.20 (95% CI = 1.05-1.37) and 1.32 (95% CI = 1.13-1.55). The results were consistent for SIRI. "Increase pattern" and "moderate stable pattern" increased the risk of CVD by 38% (HR = 1.38, 95% CI = 1.17-1.63) and 12% (HR = 1.12, 95% CI = 1.01-1.25), while no significant association was found for "decrease pattern". The highest group of annual SIRI increase and average SIRI had respective HR of 1.25 (95% CI = 1.09-1.44) and 1.39 (95% CI = 1.19-1.63). Conclusion: Dynamic status of SII and SIRI was significantly associated with risk of CVD, which highlighted that we should focus on the dynamic change of SII and SIRI. Keywords: systemic inflammation, dynamic status, prospective study, cardiovascular diseases