Combination therapy of cilostazol and bepridil suppresses recurrent ventricular fibrillation related to J-wave syndromes

• Published in: Heart rhythm Vol. 11; no. 8; pp. 1441 - 1445
• Main Authors: Shinohara, Tetsuji, MD, PhD, Ebata, Yuki, MD, Ayabe, Reika, MD, Fukui, Akira, MD, PhD, Okada, Norihiro, MD, PhD, Yufu, Kunio, MD, PhD, Nakagawa, Mikiko, MD, PhD, Takahashi, Naohiko, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014
• Subjects: Adult; Anti-Arrhythmia Agents - administration & dosage; Bepridil; Bepridil - administration & dosage; Cardiovascular; Cilostazol; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - prevention & control; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Humans; J-wave syndrome; Male; Phosphodiesterase 3 Inhibitors - administration & dosage; Recurrence; Tetrazoles - administration & dosage; Treatment Outcome; Ventricular fibrillation; Ventricular Fibrillation - drug therapy; Ventricular Fibrillation - physiopathology; Young Adult; ventricular fibrillation; BrS; early repolarization syndrome; J-wave syndrome; Brugada syndrome; ERS; ECG; transient outward current; Cilostazol; ICD; cAMP; electrocardiography; VF; I to; cyclic adenosine monophosphate; I Ca; Bepridil; implantable cardioverter-defibrillator; inward calcium current; Ito; ICa; Ventricular fibrillation
• ISSN: 1547-5271; 1556-3871
• DOI: 10.1016/j.hrthm.2014.05.001

Background Brugada syndrome and idiopathic ventricular fibrillation (VF) associated with inferolateral early repolarization patterns are termed “J-wave syndromes.” In such patients, an implantable cardioverter-defibrillator (ICD) is first-line therapy for prevention of sudden cardiac death. However, frequent ICD shocks due to recurrent VF remain serious problems. Objective The purpose of this study was to ascertain if combination therapy of cilostazol and bepridil could suppress recurrent VF. Methods We enrolled 7 patients with J-wave syndromes who experienced ICD shocks due to recurrent VF after ICD implantation. At first, cilostazol was instituted. In all subjects, palpitations due to sinus tachycardia caused by cilostazol were symptomatic. Addition of bepridil attenuated cilostazol-induced palpitations and maintained the suppressive effect of cilostazol against VF (87 ± 12 bpm to 66 ± 7 bpm, P < .01). Results Six patients remained free of VF. Three patients underwent replacement of the ICD generator 4–5 years after ICD placement. Cilostazol was discontinued 2 days before replacement because of its antiplatelet effects. In all 3 patients, temporary discontinuation of cilostazol led to the reappearance of J waves, culminating in VF and an appropriate ICD shock in 1 patient. J waves disappeared with reinstitution of cilostazol. Conclusion These data suggest that combination therapy of cilostazol and bepridil may be effective and safe in suppressing VF recurrence in some cases of J-wave syndromes.