The basal ganglia and rule-governed language use: evidence from vascular and degenerative conditions

• Published in: Brain (London, England : 1878) Vol. 128; no. 3; pp. 584 - 596
• Main Authors: Longworth, C. E., Keenan, S. E., Barker, R. A., Marslen-Wilson, W. D., Tyler, L. K.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2005; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Analysis of Variance; Anatomy; Aphasia, Broca - etiology; Aphasia, Broca - physiopathology; Aphasia, Broca - psychology; BDI = Beck Depression Index; Biological and medical sciences; CANTAB = Cambridge Neuropsychological Test Automated Battery; Central nervous system; cerebrovascular; Comprehension; Corpus Striatum - physiopathology; CSL = Centre for Speech and Language; CVA = cerebrovascular accident; Female; Fundamental and applied biological sciences. Psychology; Humans; Huntington Disease - complications; Huntington Disease - physiopathology; Huntington Disease - psychology; Huntington's disease; Language; Male; Medical sciences; Middle Aged; MMSE = Mini-Mental State Examination; NART = National Adult Reading Test; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - physiopathology; Neurodegenerative Diseases - psychology; Neurology; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Parkinson's disease; Semantics; striatum; Stroke - complications; Stroke - physiopathology; Stroke - psychology; UHDRS = Unified Huntington's Disease Rating Scale; UPDRS = Unified Parkinson's Disease Rating Scale; Vascular diseases and vascular malformations of the nervous system; Vertebrates: nervous system and sense organs; WMS = Wechsler Memory Scale; Nervous system diseases; Parkinson's disease; Central nervous system; Huntington disease; Parkinson disease; cerebrovascular; Basal ganglion; Huntington's disease; Cerebral disorder; Genetic disease; Language; striatum; Central nervous system disease; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/awh387

The Declarative/Procedural Model of Pinker, Ullman and colleagues claims that the basal ganglia are part of a fronto-striatal procedural memory system which applies grammatical rules to combine morphemes (the smallest meaningful units in language) into complex words (e.g. talk-ed, talk-ing). We tested this claim by investigating whether striatal damage or loss of its dopaminergic innervation is reliably associated with selective regular past tense deficits in patients with subcortical cerebrovascular damage, Parkinson's disease or Huntington's disease. We focused on past tense morphology since this allows us to contrast the regular past tense (jump-jumped), which is rule-based, with the irregular past tense (sleep-slept), which is not. We used elicitation and priming tasks to test patients' ability to comprehend and produce inflected forms. We found no evidence of a consistent association between striatal dysfunction and selective impairment of regular past tense morphology, suggesting that the basal ganglia are not essential for processing the regular past tense as a sequence of morphemes, either in comprehension or production, in contrast to the claims of the Declarative/Procedural Model. All patient groups showed normal activation of semantic and morphological representations in comprehension, despite difficulties suppressing semantically appropriate alternatives when trying to inflect novel verbs. This is consistent with previous reports that striatal dysfunction spares automatic activation of linguistic information, but disrupts later language processes that require inhibition of competing alternatives.