Neurokinin A-Induced Bronchial Hyperresponsiveness to Methacholine in Japanese Monkeys

• Published in: The Tohoku Journal of Experimental Medicine Vol. 159; no. 1; pp. 69 - 73
• Main Authors: TAMURA, GEN, SAKAI, KUNIO, TANIGUCHI, YUKIHIKO, IIJIMA, HIDEYA, HONMA, MASAAKI, KATSUMATA, UICHIRO, MARUYAMA, NOBUHIRO, AIZAWA, TOSHIYA, TAKISHIMA, TAMOTSU
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 1989
• Subjects: Airway Resistance - drug effects; Animals; Bronchi - drug effects; bronchial hyperresponsiveness; Dose-Response Relationship, Drug; Japanese monkeys; Lung Compliance - drug effects; Macaca; Male; methacholine; Methacholine Chloride; Methacholine Compounds - administration & dosage; Methacholine Compounds - pharmacology; neurokinin A; Neurokinin A - pharmacology; substance P; Substance P - pharmacology; Time Factors
• ISSN: 0040-8727; 1349-3329
• DOI: 10.1620/tjem.159.69

TAMURA, G., SAKAI, K., TANIGUCHI, Y., IIJIMA, H., HONMA, M., KATSUMATA, U., MARUYAMA, N., AIZAWA, T. and TAKISHIMA, T. Neurokinin A-Induced Bronchial Hyperresponsiveness to Methacholine in Japanese Monkeys. Tohoku J. Exp. Med., 1989, 159 (1), 69-73-The present study was designed to investigate whether neurokinin A (NKA) and substance P (SP) increase bronchial responsiveness to methacholine (MCh). Before and 1, 2, 3 and 4 weeks after three Japanese monkeys had inhaled 10-8M NKA and 10-8M SP for 2min, bronchial responsiveness to inhaled MCh was evaluated. Pulmonary flow resistance (R1) and dynamic lung compliance (Cdyn) were used as pulmonary function tests. Dose-response curves of R1 to inhaled MCh were shifted to the left 1 to 4 weeks after NKA treatment, compared with that obtained before treatment. However, SP treatment did not change the R1 dose-response curve. Thus, bronchial responsiveness to MCh was increased by inhalation of 10-8M NKA in Japanese monkeys.