Genetic variation of the alpha subunit of the epithelial Na+ channel influences exhaled Na+ in healthy humans

Highlights ► We explored the influence of genetics of SCNN1A on exhaled Na+ and lung diffusion. ► We found that the AA genotype had greater decrease in exhaled Na+ with albuterol. ► Both groups had a similar increase in lung conductance with albuterol.

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Bibliographic Details
Published inRespiratory physiology & neurobiology Vol. 179; no. 2; pp. 205 - 211
Main Authors Foxx-Lupo, William T, Wheatley, Courtney M, Baker, Sarah E, Cassuto, Nicholas A, Delamere, Nicholas A, Snyder, Eric M
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.12.2011
Elsevier
Subjects
ADRB2
Adult
Airway surface fluid
Beta-agonist
Biological and medical sciences
Breath condensate
Epithelial Sodium Channels - genetics
Exhalation - genetics
Female
Fundamental and applied biological sciences. Psychology
Genotype
Humans
Male
Medical Education
Polymorphism, Single Nucleotide
Pulmonary Diffusing Capacity - physiology
Pulmonary/Respiratory
Real-Time Polymerase Chain Reaction
Respiratory Function Tests
SCNN1A
Sodium - analysis
Sodium - metabolism
Vertebrates: respiratory system
Young Adult
Airway surface fluid
Beta-agonist
Breath condensate
ADRB2
SCNN1A
Human
Agonist
Ionic channel
Subunit
Respiratory system
Respiratory tract
Vertebrata
Mammalia
Sodium
Genetics
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Summary:Highlights ► We explored the influence of genetics of SCNN1A on exhaled Na+ and lung diffusion. ► We found that the AA genotype had greater decrease in exhaled Na+ with albuterol. ► Both groups had a similar increase in lung conductance with albuterol.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2011.08.008