The characteristics and patterns of drug-resistant pulmonary tuberculosis in eastern India

Background: Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug resistance is a possi...

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Published inTropical medicine and infectious disease Vol. 7; no. 9; pp. 1 - 12
Main Authors Giri, Vishal Prakash, Giri, Om Prakash, Pandey, Pooja Tripathi, Mishra, Kripa Nath, Prasad, Ram Shanker, Lal, Prabhat Kumar, Pratap, Rana, Nikhil, Nishant, Sufian, Abu, Ahmad, Reyaz, Kanodia, Shubhra
Format Journal Article
LanguageEnglish
Published Basel, Switzerland MDPI 01.09.2022
MDPI AG
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Summary:Background: Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug resistance is a possibility and should be regularly checked in from time to time. Materials and Methods: The present prospective cohort study (January 2019 to May 2022) was conducted in Darbhanga Medical College and Hospital on drug-resistant pulmonary tuberculosis patients. Sputum specimens were collected from designated centers. Rapid molecular drug-resistance testing (genotypic tests) and growth-based drug-susceptibility testing (DST) (phenotypic tests) were performed in the National Tuberculosis Elimination Program certified Laboratory. Results: A total of 268 patients with drug-resistant pulmonary tuberculosis were included in the study group. The treatment outcomes revealed as cured in 100 (37.31%); treatment completed in 43 (16.04%); died in 56 (20.89%); treatment failed in 22 (8.21%); loss of follow up in 34 (12.69%); and transferred out in 13 (4.85%) drug-resistant pulmonary tuberculosis patients. Adverse events were recorded in 199 (74.25%) of the drug-resistant pulmonary tuberculosis patients. Conclusions: Drug-resistant pulmonary tuberculosis patients are a matter of concern and need to be addressed.
Bibliography:Tropical Medicine and Infectious Disease, Vol. 7, No. 9, Sep 2022, 1-12
Informit, Melbourne (Vic)
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ISSN:2414-6366
2414-6366
DOI:10.3390/tropicalmed7090244