Interaction between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and job-related stress in insomnia: a cross-sectional study in Sichuan, China

Highlights • There was a significant interaction between 5-HTTLPR genotype and job-related stress in the risk of insomnia. • Job-related stress played a predominant role in the risk of insomnia. • The effect of 5-HTTLPR for insomnia was relatively weaker than high job-related stress.

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Bibliographic Details
Published inSleep medicine Vol. 15; no. 10; pp. 1269 - 1275
Main Authors Huang, Chan, Li, Ju, Lu, Lingeng, Ren, Xiaohui, Li, Yongru, Huang, Qian, Lan, Yajia, Wang, Yongwei
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2014
Subjects
5-HTTLPR
Adult
Alleles
China - epidemiology
Cross-Sectional Studies
Employee
Employment - psychology
Environment–gene interaction
Female
Genotype
Humans
Insomnia
Job-related stress
Male
Middle Aged
Neurology
Polymorphism, Genetic - genetics
Polymorphism, Genetic - physiology
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Plasma Membrane Transport Proteins - physiology
Sleep Initiation and Maintenance Disorders - epidemiology
Sleep Initiation and Maintenance Disorders - etiology
Sleep Initiation and Maintenance Disorders - genetics
Sleep Medicine
Stress, Psychological - complications
Surveys and Questionnaires
Susceptibility
Workplace
China
Environment–gene interaction
Employee
5-HTTLPR
Insomnia
Susceptibility
Genotype
Job-related stress
Workplace
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Summary:Highlights • There was a significant interaction between 5-HTTLPR genotype and job-related stress in the risk of insomnia. • Job-related stress played a predominant role in the risk of insomnia. • The effect of 5-HTTLPR for insomnia was relatively weaker than high job-related stress.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2014.01.023