EFFECT OF DOPA ON THE CATECHOLAMINE CONTENT OF DOG HEART AFTER HEMORRHAGIC HYPOTENSION
After hemorrhagic hypotension in dogs, myocardial norepinephrine synthesis and storage were apparently disturbed. Dibenzyline seemed to prevent death of animals subjected to hemorrhagic hypotension by causing a reduction in the bleeding volume. However, dibenzyline did not prevent a fall in arterial...
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| Published in | Japanese journal of pharmacology Vol. 15; no. 4; pp. 401 - 414 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Japanese Pharmacological Society
01.01.1965
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0021-5198 1347-3506 |
| DOI | 10.1254/jjp.15.401 |
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| Abstract | After hemorrhagic hypotension in dogs, myocardial norepinephrine synthesis and storage were apparently disturbed. Dibenzyline seemed to prevent death of animals subjected to hemorrhagic hypotension by causing a reduction in the bleeding volume. However, dibenzyline did not prevent a fall in arterial blood pressure during DOPA infusion after hemorrhagic hypotension. It is suggested that fundamental damage occurred during hemorrhagic hypotension, which caused the depletion of myocardial norepinephrine content, and also produced cardiovascular failure. |
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| AbstractList | After hemorrhagic hypotension in dogs, myocardial norepinephrine synthesis and storage were apparently disturbed. Dibenzyline seemed to prevent death of animals subjected to hemorrhagic hypotension by causing a reduction in the bleeding volume. However, dibenzyline did not prevent a fall in arterial blood pressure during DOPA infusion after hemorrhagic hypotension. It is suggested that fundamental damage occurred during hemorrhagic hypotension, which caused the depletion of myocardial norepinephrine content, and also produced cardiovascular failure. |
| Author | LYDTIN, HELMUT HASHIMOTO, YUIGHI |
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| References_xml | – reference: 12) NICKERSON, M. : “Shock” Pathogenesis and Therapy, An International Symposium, Edited by BOCK, K.D., p. 356, Academic Press Inc., New York (1962) – reference: 7) WATTS, D.T. AND BRAGG, A.D. : Proc. Soc. exp. Biol., N.Y. 96,609 (1957) – reference: 2) SARNOFF, S. J., CASE, R.B., WAITHE, P.T. AND ISAACS, J.P. : Ibid. 176,439 (1954) – reference: 20) ERLANGER, J. AND GASSER, H.S. : Amer. J. Physiol. 49,345 (1919) – reference: 22) SZAKACS, J.E. AND CANNON, A. : Amer. J. clin. Path. 30,425 (1958) – reference: 6) GOMERZ, O. AND HAMILTON, W.F. : Personal communication – reference: 9) WATTS, D.T. AND WESTFALLY, V. : Proc. Soc. exp. Biol., N.Y. 115,601 (1964) – reference: 19) POTTER, L.T. AND AXELROD, J. : Ibid. 142,299 (1963) – reference: 13) MIGONE, L. : Ibid. p. 76 (1962) – reference: 1) WIGGERS, C.J. AND WERLE, J.M. : Amer. J. Physiol. 196,421 (1947) – reference: 4) GLAVIANO, V.V. AND COLEMAN, B. : Proc. Soc. exp. Biol., N.Y. 107,761 (1961) – reference: 5) GOMERZ, O. : Fed. Proc. 21,117 (1962) – reference: 16) CHIDSEY, C.A., KAISER, G.A. AND BRAUNWALD, E. : Science 139,828 (1963) – reference: 14) LEVENSON, S.M., EINHEBER, A. AND MALM, O.J. : Fed. Proc. 20, Suppl. 9, 99 (1961) – reference: 17) BROWN, G.L. : Ciba Foundation Symposium Jointly with Committee for Symposia on Drug Action on “Adrenergic Mechanisms”, Editor for the British Pharmacological Society, p. 116, Churchill Ltd., London (1960) – reference: 21) SCHOLZ, D.E., SCHULTZ, J.C., PLEUNE, F.G., FINK, K., STEADMAN, L.T. AND WARREN, S.L. : J. din. Incest. 24,154 (1945) – reference: 10) FREEMAN, N.E., FREEDMAN, H. AND MILLER, C.C. : Amer. J. Physiol. 131,545 (1941) – reference: 3) EDWARDS, W.S., SIEGEL, A. AND BING, R.J. : J. clin. Invest. 33, 1646 (1954) – reference: 15) HASHIMOTO, Y. THIS JOURNAL 15,317 (1965) – reference: 18) POTTER, L.T. AND AXELROD, J. : J. Pharmacol. 142,291 (1963) – reference: 11) HACKEL, D.B. AND GOODALE, W.T : Circulation 11,628 (1955) – reference: 8) WALKER, W.F., ZILELI, M.S., PEUTTER, F.W., SHOEMAKER, W.C., FRIEND, D. AND MOORE, F.D. : Amer. J. Physiol. 197,773 (1959) – volume: 196 start-page: 421 year: 1947 ident: 10.1254/jjp.15.401_bib1 publication-title: Amer. J. Physiol. – volume: 49 start-page: 345 year: 1919 ident: 10.1254/jjp.15.401_bib20 publication-title: Amer. J. Physiol. doi: 10.1152/ajplegacy.1919.49.3.345 – volume: 142 start-page: 291 year: 1963 ident: 10.1254/jjp.15.401_bib18 publication-title: J. Pharmacol. – ident: 10.1254/jjp.15.401_bib13 doi: 10.1007/978-3-662-22403-8_6 – volume: 107 start-page: 761 year: 1961 ident: 10.1254/jjp.15.401_bib4 publication-title: Proc. Soc. exp. Biol., N.Y. doi: 10.3181/00379727-107-26746 – volume: 15 start-page: 317 year: 1965 ident: 10.1254/jjp.15.401_bib15 publication-title: This Journal – volume: 197 start-page: 773 year: 1959 ident: 10.1254/jjp.15.401_bib8 publication-title: Amer. J. Physiol. doi: 10.1152/ajplegacy.1959.197.4.773 – volume: 131 start-page: 545 year: 1941 ident: 10.1254/jjp.15.401_bib10 publication-title: Amer. J. Physiol. doi: 10.1152/ajplegacy.1940.131.3.545 – volume: 20, Suppl. 9 start-page: 99 year: 1961 ident: 10.1254/jjp.15.401_bib14 publication-title: Fed. Proc. – volume: 21 start-page: 117 year: 1962 ident: 10.1254/jjp.15.401_bib5 publication-title: Fed. Proc. – volume: 115 start-page: 601 year: 1964 ident: 10.1254/jjp.15.401_bib9 publication-title: Proc. Soc. exp. Biol., N.Y. doi: 10.3181/00379727-115-28981 – volume: 30 start-page: 425 year: 1958 ident: 10.1254/jjp.15.401_bib22 publication-title: Amer. J. clin. Path. doi: 10.1093/ajcp/30.5.425 – volume: 139 start-page: 828 year: 1963 ident: 10.1254/jjp.15.401_bib16 publication-title: Science doi: 10.1126/science.139.3557.828 – start-page: 116 year: 1960 ident: 10.1254/jjp.15.401_bib17 – volume: 11 start-page: 628 year: 1955 ident: 10.1254/jjp.15.401_bib11 publication-title: Circulation doi: 10.1161/01.CIR.11.4.628 – start-page: 356 year: 1962 ident: 10.1254/jjp.15.401_bib12 – volume: 142 start-page: 299 year: 1963 ident: 10.1254/jjp.15.401_bib19 publication-title: Ibid. – volume: 96 start-page: 609 year: 1957 ident: 10.1254/jjp.15.401_bib7 publication-title: Proc. Soc. exp. Biol., N.Y. doi: 10.3181/00379727-96-23553 – volume: 176 start-page: 439 year: 1954 ident: 10.1254/jjp.15.401_bib2 publication-title: Ibid. – volume: 33 start-page: 1646 year: 1954 ident: 10.1254/jjp.15.401_bib3 publication-title: J. clin. Invest. doi: 10.1172/JCI103046 – ident: 10.1254/jjp.15.401_bib6 – volume: 24 start-page: 154 year: 1945 ident: 10.1254/jjp.15.401_bib21 publication-title: J. clin. Inoest. doi: 10.1172/JCI101591 |
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| SubjectTerms | Animals Dihydroxyphenylalanine - pharmacology Dogs Epinephrine - metabolism Heart - drug effects Hypotension In Vitro Techniques Myocardium - metabolism Norepinephrine - metabolism Phenoxybenzamine - pharmacology Shock, Hemorrhagic - drug therapy |
| Title | EFFECT OF DOPA ON THE CATECHOLAMINE CONTENT OF DOG HEART AFTER HEMORRHAGIC HYPOTENSION |
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