EFFECT OF DOPA ON THE CATECHOLAMINE CONTENT OF DOG HEART AFTER HEMORRHAGIC HYPOTENSION

After hemorrhagic hypotension in dogs, myocardial norepinephrine synthesis and storage were apparently disturbed. Dibenzyline seemed to prevent death of animals subjected to hemorrhagic hypotension by causing a reduction in the bleeding volume. However, dibenzyline did not prevent a fall in arterial...

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Bibliographic Details
Published inJapanese journal of pharmacology Vol. 15; no. 4; pp. 401 - 414
Main Authors HASHIMOTO, YUIGHI, LYDTIN, HELMUT
Format Journal Article
LanguageEnglish
Published Japan The Japanese Pharmacological Society 01.01.1965
Subjects
Animals
Dihydroxyphenylalanine - pharmacology
Dogs
Epinephrine - metabolism
Heart - drug effects
Hypotension
In Vitro Techniques
Myocardium - metabolism
Norepinephrine - metabolism
Phenoxybenzamine - pharmacology
Shock, Hemorrhagic - drug therapy
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ISSN0021-5198
1347-3506
DOI10.1254/jjp.15.401

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Summary:After hemorrhagic hypotension in dogs, myocardial norepinephrine synthesis and storage were apparently disturbed. Dibenzyline seemed to prevent death of animals subjected to hemorrhagic hypotension by causing a reduction in the bleeding volume. However, dibenzyline did not prevent a fall in arterial blood pressure during DOPA infusion after hemorrhagic hypotension. It is suggested that fundamental damage occurred during hemorrhagic hypotension, which caused the depletion of myocardial norepinephrine content, and also produced cardiovascular failure.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.15.401