Genome organization and transactivation of the human immunodeficiency virus type 2

Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conse...

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Bibliographic Details
Published inNature (London) Vol. 326; no. 6114; p. 662
Main Authors Guyader, M, Emerman, M, Sonigo, P, Clavel, F, Montagnier, L, Alizon, M
Format Journal Article
LanguageEnglish
Published England 16.04.1987
Subjects
Acquired Immunodeficiency Syndrome - microbiology
Amino Acid Sequence
Base Sequence
Deltaretrovirus - genetics
Deltaretrovirus - isolation & purification
DNA - analysis
Gene Products, gag
Genes
Genes, Viral
Humans
Retroviridae Proteins - genetics
Sequence Homology, Nucleic Acid
Viral Envelope Proteins - genetics
Viral Proteins - genetics
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Summary:Analysis of the nucleotide sequence of the human retrovirus associated with AIDS in West Africa, HIV-2, shows that it is evolutionarily distant from the previously characterized HIV-1. We suggest that these viruses existed long before the current AIDS epidemics. Their biological properties are conserved in spite of limited sequence homology; this may help the determination of the structure-function relationships of the different viral elements.
ISSN:0028-0836
DOI:10.1038/326662a0