p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

• Published in: Cell Vol. 137; no. 6; pp. 1001 - 1004
• Main Authors: Moscat, Jorge, Diaz-Meco, Maria T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.06.2009
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Apoptosis; Autophagy; Humans; Neoplasms - metabolism; NF-kappa B - metabolism; Sequestosome-1 Protein

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These f...