p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These f...

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Bibliographic Details
Published inCell Vol. 137; no. 6; pp. 1001 - 1004
Main Authors Moscat, Jorge, Diaz-Meco, Maria T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.06.2009
Subjects
Adaptor Proteins, Signal Transducing - metabolism
Apoptosis
Autophagy
Humans
Neoplasms - metabolism
NF-kappa B - metabolism
Sequestosome-1 Protein
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Summary:The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
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ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.05.023