Quantitative Determination of Hydrazines derived from Isoniazid in Man

Hydrazine formation took place in man after the oral administration of isoniazid. The excreted amount of free hydrazine in human urine was determined quantitatively by the new method, i.e. mass fragmentography using 15N-hydrazine as an internal standard. The unchanged isoniazid and the other metabol...

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Published inChemical & pharmaceutical bulletin Vol. 25; no. 10; pp. 2796 - 2800
Main Authors IGUCHI, SADAO, GOROMARU, TSUYOSHI, NODA, ATSUKO, MATSUYAMA, KENJI, SOGABE, KEIZO
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1977
Subjects
Hydrazines - analysis
internal standard-15N-hydrazine
Isoniazid - metabolism
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Summary:Hydrazine formation took place in man after the oral administration of isoniazid. The excreted amount of free hydrazine in human urine was determined quantitatively by the new method, i.e. mass fragmentography using 15N-hydrazine as an internal standard. The unchanged isoniazid and the other metabolites, acetylisoniazid, monoacetylhydrazine and diacetylhydrazine were simultaneously analyzed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.25.2796