The Kinetics of Phase Separation in Asymmetric Membranes

Phase separation in a model asymmetric membrane is studied using Monte Carlo techniques. The membrane comprises two species of particles, which mimic different lipids in lipid bilayers and separately possess either zero or non-zero spontaneous curvatures. We study the influence of phase separation o...

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Bibliographic Details
Published inBiophysical journal Vol. 88; no. 6; pp. 4072 - 4083
Main Authors Wallace, Elizabeth J., Hooper, Nigel M., Olmsted, Peter D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2005
Biophysical Society
Subjects
Biophysical Phenomena
Biophysics
Cellular biology
In Vitro Techniques
Kinetics
Lipid Bilayers - chemistry
Lipids
Membrane Microdomains - chemistry
Membrane separation
Membranes
Models, Chemical
Thermodynamics
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Summary:Phase separation in a model asymmetric membrane is studied using Monte Carlo techniques. The membrane comprises two species of particles, which mimic different lipids in lipid bilayers and separately possess either zero or non-zero spontaneous curvatures. We study the influence of phase separation on membrane shape and the influence of the coupling of composition and height dynamics on phase separation and domain growth, via both the degree of shape asymmetry and relative kinetic coefficients for height relaxation.
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Address reprint requests to Peter D. Olmsted, Tel.: 44-113-343-3830; E-mail: p.d.olmsted@leeds.ac.uk.
ISSN:0006-3495
1542-0086
DOI:10.1529/biophysj.104.054288