Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies

• Published in: The American journal of clinical nutrition Vol. 99; no. 3; pp. 506 - 516
• Main Authors: Leventakou, Vasiliki, Roumeliotaki, Theano, Martinez, David, Barros, Henrique, Brantsaeter, Anne-Lise, Casas, Maribel, Charles, Marie-Aline, Cordier, Sylvaine, Eggesbø, Merete, van Eijsden, Manon, Forastiere, Francesco, Gehring, Ulrike, Govarts, Eva, Halldórsson, Thorhallur I, Hanke, Wojciech, Haugen, Margaretha, Heppe, Denise HM, Heude, Barbara, Inskip, Hazel M, Jaddoe, Vincent WV, Jansen, Maria, Kelleher, Cecily, Meltzer, Helle Margrete, Merletti, Franco, Moltó-Puigmartí, Carolina, Mommers, Monique, Murcia, Mario, Oliveira, Andreia, Olsen, Sjúrður F, Pele, Fabienne, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Robinson, Siân M, Stigum, Hein, Strøm, Marin, Sunyer, Jordi, Thijs, Carel, Viljoen, Karien, Vrijkotte, Tanja GM, Wijga, Alet H, Kogevinas, Manolis, Vrijheid, Martine, Chatzi, Leda
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition 01.03.2014; American Society for Clinical Nutrition, Inc
• Subjects: Animals; Birth weight; Birth Weight - drug effects; clinical nutrition; Cohort Studies; environmental exposure; Europe - epidemiology; exposure pathways; Female; fetal development; Fetal Development - drug effects; Fish; fish consumption; Fishes; Food Contamination; gestational age; Health Promotion; Humans; Longitudinal Studies; Maternal Nutritional Physiological Phenomena; Meta-analysis; neonates; nutrients; Nutrition Policy; obesity; Pollutants; Pregnancy; premature birth; Premature Birth - epidemiology; Premature Birth - etiology; Premature Birth - prevention & control; Prospective Studies; Risk; Risk assessment; Seafood - adverse effects; Water Pollutants, Chemical - toxicity; women; Europe
• ISSN: 0002-9165; 1938-3207
• DOI: 10.3945/ajcn.113.067421

Background: Fish is a rich source of essential nutrients for fetal development, but in contrast, it is also a well-known route of exposure to environmental pollutants.Objective: We assessed whether fish intake during pregnancy is associated with fetal growth and the length of gestation in a panel of European birth cohort studies.Design: The study sample of 151,880 mother-child pairs was derived from 19 population-based European birth cohort studies. Individual data from cohorts were pooled and harmonized. Adjusted cohort-specific effect estimates were combined by using a random- and fixed-effects meta-analysis.Results: Women who ate fish >1 time/wk during pregnancy had lower risk of preterm birth than did women who rarely ate fish (≤1 time/wk); the adjusted RR of fish intake >1 but <3 times/wk was 0.87 (95% CI: 0.82, 0.92), and for intake ≥3 times/wk, the adjusted RR was 0.89 (95% CI: 0.84, 0.96). Women with a higher intake of fish during pregnancy gave birth to neonates with a higher birth weight by 8.9 g (95% CI: 3.3, 14.6 g) for >1 but <3 times/wk and 15.2 g (95% CI: 8.9, 21.5 g) for ≥3 times/wk independent of gestational age. The association was greater in smokers and in overweight or obese women. Findings were consistent across cohorts.Conclusion: This large, international study indicates that moderate fish intake during pregnancy is associated with lower risk of preterm birth and a small but significant increase in birth weight.